In this review glycosidase activated prodrugs that target cancer cells are discussed.
Glycosylated prodrugs undergo enzymatic bioconversion, cleaving the prodrug to release …

Glycosidases are ubiquitous enzymes that catalyze the hydrolysis of glycosidic linkages in
oligosaccharides and glycoconjugates. These enzymes play a vital role in a wide variety of …

The design of innovative therapeutic strategies enabling the selective destruction of tumor
cells while sparing healthy tissues remains highly challenging in cancer therapy. Here, we …

Developing new therapeutic strategies that damage tumour cells without harming normal
tissues is among the primary obstacles in chemotherapy. In this study, a novel β …

The development of selective anticancer drugs avoiding side effects met in the course of
almost all current treatments is of major interest for cancer patients. Here, we report on a …

Current chemotherapies suffer low specificity and sometimes drug resistance. Neutrophil
elastase activity in cancer is associated with poor prognosis and metastasis settlement …

The albumin-based drug delivery system is an effective drug delivery strategy for traditional
chemotherapeutic drugs that can improve their antitumour efficacies and reduce systemic …

The discovery of tumour-associated markers is of major interest for the development of
selective cancer chemotherapy. Within this framework, we introduced the concept of induced …

Long considered as no more than biological waste meant to be eliminated in urine,
glucuronides have recently contributed to tremendous developments in the biomedical field …

Real‐time tracking of prodrug uptake, delivery and activation in vivo represents a major
challenge for prodrug development. Herein, we demonstrate the use of novel glycosylated …