Wilms tumour (WT) is a childhood embryonal tumour that is paradigmatic of the intersection
between disrupted organogenesis and tumorigenesis. Many WT genes play a critical (non …

Liquid biopsies have piqued the interest of researchers as a new tumor diagnosis technique
due to their unique benefits of non-invasiveness, sensitivity, and convenience. Recent …

Abnormally excessive growth results from perturbation of a complex interplay of genetic,
epigenetic, and hormonal factors that orchestrate human growth. Overgrowth syndromes …

The phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) signaling
pathway has been implicated as a cancer target. Big pharma players and small companies …

Macrocephaly affects up to 5% of the pediatric population and is defined as an abnormally
large head with an occipitofrontal circumference (OFC)> 2 standard deviations (SD) above …

Imprinted genes play diverse roles in mammalian development, homeostasis, and disease.
Most imprinted chromosomal domains express one or more long non-coding RNAs …

Background Appropriate placental supply of nutrients and oxygen is essential for fetal
growth and development, neonatal health, and lifelong well-being. Conversely, abnormal …

Pediatric renal tumors account for 3%–11% of childhood cancers, the most common of
which is Wilms tumor or nephroblastoma. Epidemiology plays a key role in cancer …

Since previous consensus-based Wilms tumour (WT) surveillance guidelines were
published, novel genes and syndromes associated with WT risk have been identified, and …

DNA variants that arise after conception can show mosaicism, varying in presence and
extent among tissues. Mosaic variants have been reported in Mendelian diseases, but …