Depending on multiple factors DNA damage leads either to cell cycle arrest or apoptosis.
One of the main players deciding the fate of a cell is the tumor suppressor p53 that …

The p53 and nuclear factor-κB (NF-κB) pathways play crucial roles in human cancer, in
which inactivation of p53 and hyperactivation of NF-κB is a common occurrence. Activation …

Deregulated expression of COX-2 has been causally linked to development, progression,
and outcome of several types of human cancer. We describe a novel fundamental level of …

Quercetin, a polyphenolic bioflavonoid, possesses multiple pharmacological actions
including anti-inflammatory and antitumor properties. However, the precise action …

Gastric carcinoma is one of the most common cancers and lethal malignancies worldwide.
Thus far, the regulatory mechanisms of its aggressiveness are still poorly understood. To …

Chronic inflammation as an important epigenetic and environmental factor for putative
tumorigenesis and tumor progression may be associated with specific activation of Toll-like …

Intensive study of the TP53 gene over the last three decades has revealed a highly complex
network of factors that regulate its performance. The gene has several promoters, alternative …

Antitumor immune polarization is a key predictor of clinical outcomes to cancer therapy. An
emerging concept influencing clinical outcome involves the spatial location of CD8+ T cells …

Lung cancer is the leading cause of cancer-related deaths worldwide. Despite decades of
research, the treatment options for lung cancer patients remain inadequate, either to offer a …

Inflammation underlies the development and progression of a number of skin disorders
including psoriasis, atopic dermatitis and cancer. Therefore, novel antiinflammatory agents …