Alzheimer's disease (AD) is the most common chronic neurodegenerative disease
worldwide. It causes cognitive dysfunction, such as aphasia and agnosia, and mental …

Cellular senescence is a state of irreversible cell cycle arrest in response to an array of
cellular stresses. An important role for senescence has been shown for a number of …

Aging is a prominent risk factor for neurodegenerative disorders (NDDs); however, the
molecular mechanisms rendering the aged brain particularly susceptible to …

Stable isotope labeling by amino acids in cell culture (SILAC) coupled to data-dependent
acquisition (DDA) is a common approach to quantitative proteomics with the desirable …

Aging slowly erodes skeletal muscle strength and mass, eventually leading to profound
functional deficits and muscle atrophy. The molecular mechanisms of skeletal muscle aging …

The chemistry of life requires a solvent, which for life on Earth is water. Several alternative
solvents have been suggested, but there is little quantitative analysis of their suitability as …

Cells continually degrade and replace damaged proteins. However, the high energetic
demand of protein turnover generates reactive oxygen species that compromise the long …

In spite of its central role in biology and disease, protein turnover is a largely understudied
aspect of most proteomic studies due to the complexity of computational workflows that …

The oxidation of methionine has emerged as an important post-translational modification of
proteins. A number of studies have suggested that the oxidation of methionines in select …

The mechanisms of aging are described at the molecular, cell, tissue, and systemic levels.
Primary age-dependent molecular lesions activate the cell stress response to compensate …