The stress–diathesis model posits that suicide is the result of an interaction between state-
dependent (environmental) stressors and a trait-like diathesis or susceptibility to suicidal …

Stress initiates adaptive processes that allow the organism to physiologically cope with
prolonged or intermittent exposure to real or perceived threats. A major component of this …

Stress and glucocorticoid hormones regulate hippocampal neurogenesis, but the molecular
mechanisms mediating these effects are poorly understood. Here we identify the …

Coping with stress is fundamental for mental health, but understanding of the molecular
neurobiology of stress is still in its infancy. Adult neurogenesis is well known to be regulated …

Chronic psychosocial stress is increasingly being recognised as a risk factor for sporadic
Alzheimer's disease (AD). The hypothalamic–pituitary–adrenal axis (HPA axis) is the major …

A stressful event results in secretion of glucocorticoid hormones, which bind to
mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs) in the hippocampus to …

It is well accepted that events that interfere with the normal program of neuronal
differentiation and brain maturation may be relevant for the etiology of psychiatric disorders …

Background Major depressive disorder affects more than 15% of the population across their
lifespan. In this study, we used the well-characterized unpredictable chronic mild stress …

Chronic restraint stress leads to increases in brain derived neurotrophic factor (BDNF)
mRNA and protein in some regions of the brain, eg the basal lateral amygdala (BLA) but …

Adult hippocampal neurogenesis is implicated in antidepressant action, stress responses,
and cognitive functioning. The hippocampus is functionally segregated along its longitudinal …