Recent genome-wide association studies (GWAS) have identified multiple susceptibility loci
for immunoglobulin A nephropathy (IgAN), the most common form of glomerulonephritis …

Studies of molecular and cellular interactions involved in the pathogenesis of IgA
nephropathy have revealed the autoimmune nature of this most common primary …

End-stage renal disease (ESRD) is a major public health problem, affecting 1 in 1,000
individuals and with an annual death rate of 20% despite dialysis treatment 1, 2. IgA …

Primary IgA nephropathy (IgAN) is characterized by recurrent episodes of macroscopic
hematuria accompanied by upper respiratory tract infections or persistent asymptomatic …

Several lines of evidence suggest that genetic factors have an important role in the
pathogenesis of immunoglobulin A (IgA) nephropathy. We report the prevalence of familial …

Several new findings emerged recently from biochemical, genetic, and molecular studies of
patients with IgA nephropathy. It appears that immunoglobulin A1-secreting cells of IgA …

Genetic factors are considered to be involved in the initiation and progression of IgA
nephropathy (IgAN) on the basis of racial differences in the prevalence and familial …

IgA nephropathy is the most common form of primary glomerulonephritis. Variations in
clinical manifestations indicate that a diagnosis of IgA nephropathy encompasses multiple …

Whereas members of the Navajo Nation are at high risk for diabetes mellitus, there are no
recent published estimates of the burden of end-stage renal disease (ESRD), an important …

Background Immunoglobulin A nephropathy (IgAN) can exist as a primary
glomerulonephritis (GN) or in association with various clinical conditions, suggesting that it …