Sphingolipids are a specialized group of lipids essential to the composition of the plasma
membrane of many cell types; however, they are primarily localized within the nervous …

The importance of neuroglia in maintaining normal brain function under physiological and
pathological conditions has been supported by growing evidence in recent years. The most …

Over the past decade, it was found that relatively simple sphingolipids, such as ceramide,
sphingosine, sphingosine-1-phosphate, and glucosylceramide play important roles in …

Astrocytes are the main support cells of the central nervous system. They also participate in
neuroimmune reactions. In response to pathological and immune stimuli, astrocytes …

Cognitive processes, particularly learning and memory, are crucial brain mechanisms
mediating the successful adaptation of individuals to constantly changing environmental …

Astrocytes are the most abundant glial cell in the central nervous system and are involved in
multiple processes including metabolic homeostasis, blood brain barrier regulation and …

Recent data highlight the important roles of the gut microbiome, gut permeability, and
alterations in mitochondria functioning in the pathophysiology of multiple sclerosis (MS) …

Autophagy involves the sequestration and delivery of cytoplasmic materials to lysosomes,
where proteins, lipids, and organelles are degraded and recycled. According to the way the …

Inflammatory mechanisms are increasingly recognized as important contributors to the
pathogenesis of neurodegenerative diseases, including Lewy body dementia (LBD). Our …

Sphingolipids are ubiquitous building blocks of eukaryotic cell membranes that function as
signaling molecules for regulating a diverse range of cellular processes, including cell …