5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

Introduction Sexual desire is controlled by brain systems involved in sexual excitation and
inhibition. Hypoactive sexual desire disorder (HSDD) may result from hypofunctional …

Selective serotonin reuptake inhibitors (SSRIs) are the most widely prescribed
antidepressant class today and exert their antidepressant-like effects by increasing synaptic …

Background The efficiency of drug development defined as a number of successfully
launched new pharmaceuticals normalized by financial investments has significantly …

Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

Abstract Introduction Hypoactive Sexual Desire Disorder (HSDD) is defined in the
Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Revised (DSM-IV-TR) …

ABSTRACT Introduction Hypoactive Sexual Desire Disorder (HSDD) is characterized by low
sexual desire that causes marked distress or interpersonal difficulty. Aim The aim of this …

Abstract Serotonin (5-HT) 2C receptors play an important role in the modulation of
monoaminergic transmission, mood, motor behaviour, appetite and endocrine secretion …

5-HT2 receptors are G-protein coupled receptors that currently comprise threesubtypes: 5-
HT2A, 5-HT2B and 5-HT2C receptors. The subtypes are related in theirmolecular structure …

ABSTRACT Introduction Hypoactive Sexual Desire Disorder (HSDD) is the most common
form of Female Sexual Dysfunction and is characterized by low sexual desire that causes …