Beyond fluidity: the role of lipid unsaturation in membrane function

T Harayama, B Antonny - Cold Spring Harbor …, 2023 - cshperspectives.cshlp.org
The number of double bonds in the acyl chains of membrane lipids varies tremendously at
all scales of life, from the organism level to the subcellular level, where differences in lipid …

Inflammation and cardiovascular disease: are marine phospholipids the answer?

R Lordan, S Redfern, A Tsoupras, I Zabetakis - Food & function, 2020 - pubs.rsc.org
Since the discovery that Greenlandic Innuits had a lower risk of developing cardiovascular
diseases (CVD) due to their diet of fish and as a consequence high polyunsaturated fatty …

[HTML][HTML] EPA and DHA differentially modulate membrane elasticity in the presence of cholesterol

ML Jacobs, HA Faizi, JA Peruzzi, PM Vlahovska… - Biophysical …, 2021 - cell.com
Polyunsaturated fatty acids (PUFAs) modify the activity of a wide range of membrane
proteins and are increasingly hypothesized to modulate protein activity by indirectly altering …

Resolvin E1 derived from eicosapentaenoic acid prevents hyperinsulinemia and hyperglycemia in a host genetic manner

A Pal, AE Al‐Shaer, W Guesdon, MJ Torres… - The FASEB …, 2020 - Wiley Online Library
Eicosapentaenoic acid (EPA) has garnered attention after the success of the REDUCE‐IT
trial, which contradicted previous conclusions on EPA for cardiovascular disease risk. Here …

[HTML][HTML] Plasma metabolite changes in dairy cows during parturition identified using untargeted metabolomics

ZZ Luo, LH Shen, J Jiang, YX Huang, LP Bai… - Journal of dairy …, 2019 - Elsevier
The metabolic responses of cows undergo substantial changes during the transition from
late pregnancy to early lactation. However, the molecular mechanisms associated with these …

Docosahexaenoic acid regulates the formation of lipid rafts: A unified view from experiment and simulation

SR Wassall, X Leng, SW Canner… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Abstract Docosahexaenoic acid (DHA, 22: 6) is an n− 3 polyunsaturated fatty acid (n− 3
PUFA) that influences immunological, metabolic, and neurological responses through …

[HTML][HTML] Identification of PUFA interaction sites on the cardiac potassium channel KCNQ1

S Yazdi, J Nikesjö, W Miranda, V Corradi… - Journal of General …, 2021 - rupress.org
Polyunsaturated fatty acids (PUFAs), but not saturated fatty acids, modulate ion channels
such as the cardiac KCNQ1 channel, although the mechanism is not completely understood …

Do eicosapentaenoic acid and docosahexaenoic acid have the potential to compete against each other?

A Pal, AH Metherel, L Fiabane, N Buddenbaum… - Nutrients, 2020 - mdpi.com
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are n-3 polyunsaturated
fatty acids (PUFAs) consumed in low abundance in the Western diet. Increased consumption …

EPA's pleiotropic mechanisms of action: a narrative review

JR Nelson, MJ Budoff, OR Wani, V Le… - Postgraduate …, 2021 - Taylor & Francis
Treatment with icosapent ethyl 4 g/day, a highly purified and stable ethyl ester of
eicosapentaenoic acid (EPA), demonstrated a significant reduction in atherosclerotic …

Effect of silver nanoparticles on gill membranes of common carp: Modification of fatty acid profile, lipid peroxidation and membrane fluidity

QQ Xiang, D Wang, JL Zhang, CZ Ding, X Luo… - Environmental …, 2020 - Elsevier
Although the toxicity of silver nanoparticles (AgNPs) in aquatic organisms has been
extensively investigated, the mechanism by which AgNPs damage membranes remains …