Altered iron metabolism and impact in cancer biology, metastasis, and immunology
Iron is an essential nutrient that plays a complex role in cancer biology. Iron metabolism
must be tightly controlled within cells. Whilst fundamental to many cellular processes and …
must be tightly controlled within cells. Whilst fundamental to many cellular processes and …
Tumor microenvironment differences between primary tumor and brain metastases
B Cacho-Díaz, DR García-Botello… - Journal of Translational …, 2020 - Springer
The present review aimed to discuss contemporary scientific literature involving differences
between the tumor microenvironment (TME) in melanoma, lung cancer, and breast cancer in …
between the tumor microenvironment (TME) in melanoma, lung cancer, and breast cancer in …
Role of the blood-brain barrier in the formation of brain metastases
The majority of brain metastases originate from lung cancer, breast cancer and malignant
melanoma. In order to reach the brain, parenchyma metastatic cells have to transmigrate …
melanoma. In order to reach the brain, parenchyma metastatic cells have to transmigrate …
Brain metastases: pathobiology and emerging targeted therapies
M Preusser, D Capper, A Ilhan-Mutlu, AS Berghoff… - Acta …, 2012 - Springer
Brain metastases (BM) are common in cancer patients and are associated with high
morbidity and poor prognosis, even after intensive multimodal therapy including resection …
morbidity and poor prognosis, even after intensive multimodal therapy including resection …
Transmigration of melanoma cells through the blood-brain barrier: role of endothelial tight junctions and melanoma-released serine proteases
Malignant melanoma represents the third common cause of brain metastasis, having the
highest propensity to metastasize to the brain of all primary neoplasms in adults. Since the …
highest propensity to metastasize to the brain of all primary neoplasms in adults. Since the …
The resurgence of antibody drug conjugates in cancer therapeutics: novel targets and payloads
V Boni, MR Sharma, A Patnaik - American Society of Clinical …, 2020 - ascopubs.org
Antibody drug conjugates (ADCs) are an emerging class of therapeutics that consist of a
cytotoxic agent linked covalently to an antibody, which is directed toward a specific cell …
cytotoxic agent linked covalently to an antibody, which is directed toward a specific cell …
Molecular evolution of the transferrin family and associated receptors
LA Lambert - Biochimica et Biophysica Acta (BBA)-General Subjects, 2012 - Elsevier
BACKGROUND: In vertebrates, serum transferrins are essential iron transporters that have
bind and release Fe (III) in response to receptor binding and changes in pH. Some family …
bind and release Fe (III) in response to receptor binding and changes in pH. Some family …
Insights into the molecular mechanisms mediating extravasation in brain metastasis of breast cancer, melanoma, and lung cancer
R Alsabbagh, M Ahmed, MAY Alqudah, R Hamoudi… - Cancers, 2023 - mdpi.com
Simple Summary Despite the advancements in systemic treatments, the incidence of brain
metastasis (BM) is increasing. BM is a multi-step cascade. One critical event in BM is the …
metastasis (BM) is increasing. BM is a multi-step cascade. One critical event in BM is the …
In vitro models of molecular and nano-particle transport across the blood-brain barrier
The blood-brain barrier (BBB) is the tightest endothelial barrier in humans. Characterized by
the presence of tight endothelial junctions and adherens junctions, the primary function of …
the presence of tight endothelial junctions and adherens junctions, the primary function of …
New era in the management of melanoma brain metastases
HA Tawbi, C Boutros, D Kok, C Robert… - American Society of …, 2018 - ascopubs.org
The remarkable advances in the systemic therapy of metastatic melanoma have now
extended the 1-year overall survival rate from 25% to nearing 85%. Systemic treatment in …
extended the 1-year overall survival rate from 25% to nearing 85%. Systemic treatment in …