Retinal ganglion cell (RGC) death in glaucoma and other optic neuropathies results in
irreversible vision loss due to the mammalian central nervous system's limited regenerative …

Glaucoma, the leading cause of irreversible blindness, is a heterogeneous group of
diseases characterized by progressive loss of retinal ganglion cells (RGCs) and their axons …

We present FLASH-seq (FS), a full-length single-cell RNA sequencing (scRNA-seq) method
with increased sensitivity and reduced hands-on time compared to Smart-seq3. The entire …

In the mammalian retina, a metabolic ecosystem exists in which photoreceptors acquire
glucose from the choriocapillaris with the help of the retinal pigment epithelium (RPE). While …

The retina is highly susceptible to the generation of toxic reactive oxygen species (ROS) that
disrupt the normal operations of retinal cells. The glutathione (GSH) antioxidant system …

Photoreceptors, the primary site of phototransduction in the retina, require energy and
metabolites to constantly renew their outer segments. They preferentially consume most …

The postmitotic retina is highly metabolic and the photoreceptors depend on aerobic
glycolysis for an energy source and cellular anabolic activities. Lactate dehydrogenase A …

Background Right ventricle failure (RVF) is a progressive heart disease that has yet to be
fully understood at the molecular level. Elevated M-type pyruvate kinase 2 (PKM2) …

Finding reliable cheap sources for producing chemicals and materials is always
challenging. During recent decades, photosynthetic organisms such as cyanobacteria …

The light-absorbing retina has an exceptionally high oxygen demand, which imposes two
conflicting needs: high rates of blood perfusion and an unobstructed light path devoid of …