Ocular discomfort and eye pain are frequently reported by patients with dry eye disease
(DED), and their management remains a real therapeutic challenge for the Ophthalmologist …

Background Neuropeptides play a critical role in regulating pain and inflammation. Despite
accumulating evidence has further uncovered the novel functions and mechanisms of …

Cancer still represents one of the biggest challenges in current medical practice. Among
different types of cancer, oral cancer has a huge impact on patients due to its great visibility …

Background. The use of easily accessible biomarkers for assessing young patients' health is
weighty. This cohort study is aimed at measuring stress/immune biomarkers in the saliva of …

This study aimed to evaluate the mucoadhesive and regenerative properties of a novel
lubricating multimolecular ophthalmic solution (GlicoPro®) extracted from snail mucus and …

Purpose: Opiorphin is an endogenous inhibitor of enkephalin-degrading enzymes. It has a
strong analgesic effect in chemical and mechanical pain models. We aimed to evaluate the …

Background Patients who suffer from anorexia nervosa (AN) are characterized by
exceedingly lower body weight, micro-and macro-nutrient deficiencies, and hyposalivation …

Pain is one of the most common complaints leading to a pediatric emergency department
visit and is associated with various painful procedures, leading to increased anxiety and …

Supramolecular solvents (dubbed SUPRAS) are gaining momentum as extractants of
compounds of interest from complex matrixes such as foodstuff and biological and …

Objective Opiorphin is a pentapeptide secreted in saliva and has a strong analgesic effect.
Salivary opiorphin has been shown to increase in orofacial pain and may act as a pain …