Effect of S-adenosylmethionine tablets on the reduction of age-related mental decline in dogs: a double-blinded, placebo-controlled trial.

CA Rème, V Dramard, L Kern, J Hofmans… - … : research in applied …, 2008 - europepmc.org
Oral S-adenosylmethionine (SAMe) tosylate supplementation (Novifit tablets, Virbac) was
evaluated as a dietary aid for the management of age-related mental impairment in dogs …

Natural remedies for anxiety disorders: potential use and clinical applications

G Kinrys, E Coleman, E Rothstein - Depression and anxiety, 2009 - Wiley Online Library
Background: Natural remedies have been widely used and generally accepted as
established treatments of depressive disorders, leading to the investigation of their potential …

A new method for isolation of S-adenosylmethionine (SAM)-accumulating yeast

M Shobayashi, N Mukai, K Iwashita, Y Hiraga… - Applied microbiology …, 2006 - Springer
S-Adenosylmethionine (SAM) is an important metabolite that participates in many reactions
as a methyl group donor in all organisms, and has attracted much interest in clinical …

How microbes shape their communities? A microbial community model based on functional genes

X Jiang, X Li, L Yang, C Liu, Q Wang… - Genomics …, 2019 - academic.oup.com
Exploring the mechanisms of maintaining microbial community structure is important to
understand biofilm development or microbiota dysbiosis. In this paper, we propose a …

S-adenosyl-l-methionine antidepressant-like effects involve activation of 5-HT1A receptors

AJ Sales, IS Maciel, CC Crestani, FS Guimarães… - Neurochemistry …, 2023 - Elsevier
Abstract S-adenosyl-l-methionine (SAMe), a methyl donor, induces antidepressant effects in
preclinical and clinical studies of depression. However, the mechanisms behind these …

A genetic method to enhance the accumulation of S-adenosylmethionine in yeast

M Kanai, M Mizunuma, T Fujii, H Iefuji - Applied Microbiology and …, 2017 - Springer
S-Adenosylmethionine (SAM) is a key component of sulphur amino acid metabolism in living
organisms and is synthesised from methionine and adenosine triphosphate by methionine …

Global gene expression profiling of the polyamine system in suicide completers

LM Fiori, A Bureau, A Labbe, J Croteau… - International journal …, 2011 - academic.oup.com
In recent years, gene expression, genetic association, and metabolic studies have
implicated the polyamine system in psychiatric conditions, including suicide. Given the …

Adenosine kinase-deficient mutant of Saccharomyces cerevisiae accumulates S-adenosylmethionine because of an enhanced methionine biosynthesis pathway

M Kanai, M Masuda, Y Takaoka, H Ikeda… - Applied Microbiology …, 2013 - Springer
To isolate an S-adenosylmethionine (SAM)-accumulating yeast strain and to develop a more
efficient method of producing SAM, we screened methionine-resistant strains using the yeast …

Immunoassay of S-adenosylmethionine and S-adenosylhomocysteine: the methylation index as a biomarker for disease and health status

X Hao, Y Huang, M Qiu, C Yin, H Ren, H Gan, H Li… - BMC Research …, 2016 - Springer
Abstract Background S-Adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) are
relevant to a variety of diseases. Previous reports that quantified SAM and SAH were based …

Dissection of signal transduction pathways as a tool for the development of targeted therapies of hepatocellular carcinoma

DF Calvisi, RM Pascale, F Feo - Reviews on recent clinical …, 2007 - ingentaconnect.com
Genomic instability during hepatocarcinogenesis causes changes in signal transduction
network. Strategies for identification of new markers/therapeutic targets include discovery of …