Bromodomain biology and drug discovery
N Zaware, MM Zhou - Nature structural & molecular biology, 2019 - nature.com
The bromodomain (BrD) is a conserved structural module found in chromatin-and
transcription-associated proteins that acts as the primary reader for acetylated lysine …
transcription-associated proteins that acts as the primary reader for acetylated lysine …
ISWI chromatin remodeling complexes in the DNA damage response
Regulation of chromatin structure is an essential component of the DNA damage response
(DDR), which effectively preserves the integrity of DNA by a network of multiple DNA repair …
(DDR), which effectively preserves the integrity of DNA by a network of multiple DNA repair …
CECR2 drives breast cancer metastasis by promoting NF-κB signaling and macrophage-mediated immune suppression
Metastasis is the major cause of cancer-related deaths due to the lack of effective therapies.
Emerging evidence suggests that certain epigenetic and transcriptional regulators drive …
Emerging evidence suggests that certain epigenetic and transcriptional regulators drive …
CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality
H Hoffmeister, A Fuchs, F Erdel, S Pinz… - Nucleic Acids …, 2017 - academic.oup.com
Abstract CHD3 and CHD4 (C hromodomain H elicase D NA binding protein), two highly
similar representatives of the Mi-2 subfamily of SF2 helicases, are coexpressed in many cell …
similar representatives of the Mi-2 subfamily of SF2 helicases, are coexpressed in many cell …
Expansion of the ISWI chromatin remodeler family with new active complexes
ISWI chromatin remodelers mobilize nucleosomes to control DNA accessibility. Complexes
isolated to date pair one of six regulatory subunits with one of two highly similar ATP ases …
isolated to date pair one of six regulatory subunits with one of two highly similar ATP ases …
[HTML][HTML] The role of ISWI chromatin remodeling complexes in brain development and neurodevelopmental disorders
LR Goodwin, DJ Picketts - Molecular and Cellular Neuroscience, 2018 - Elsevier
Abstract The mammalian ISWI (Imitation Switch) genes SMARCA1 and SMARCA5 encode
the ATP-dependent chromatin remodeling proteins SNF2L and SNF2H. The ISWI proteins …
the ATP-dependent chromatin remodeling proteins SNF2L and SNF2H. The ISWI proteins …
The mouse INO80 chromatin-remodeling complex is an essential meiotic factor for spermatogenesis
DW Serber, JS Runge, DU Menon… - Biology of …, 2016 - academic.oup.com
The ability to faithfully transmit genetic information across generations via the germ cells is a
critical aspect of mammalian reproduction. The process of germ cell development requires a …
critical aspect of mammalian reproduction. The process of germ cell development requires a …
Cytotoxic activity of bromodomain inhibitor NVS-CECR2-1 on human cancer cells
Bromodomain (BRD), a protein module that recognizes acetylated lysine residues on
histones and other proteins, has recently emerged as a promising therapeutic target for …
histones and other proteins, has recently emerged as a promising therapeutic target for …
Mouse BAZ1A (ACF1) is dispensable for double-strand break repair but is essential for averting improper gene expression during spermatogenesis
ATP-dependent chromatin remodelers control DNA access for transcription, recombination,
and other processes. Acf1 (also known as BAZ1A in mammals) is a defining subunit of the …
and other processes. Acf1 (also known as BAZ1A in mammals) is a defining subunit of the …
Genome-wide screen of human bromodomain-containing proteins identifies Cecr2 as a novel DNA damage response protein
SK Lee, EJ Park, HS Lee, YS Lee, J Kwon - Molecules and cells, 2012 - Springer
The formation of γ-H2AX foci after DNA double strand breaks (DSBs) is crucial for the
cellular response to this lethal DNA damage. We previously have shown that BRG1, a …
cellular response to this lethal DNA damage. We previously have shown that BRG1, a …