Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …

Osteoarthritis (OA) is the most common degenerative joint disease and a major cause of
pain and disability in adult individuals. The etiology of OA includes joint injury, obesity …

Osteoarthritis (OA) is the most common joint disorder and affects approximately half of the
aged population. Current treatments for OA are largely palliative until the articular cartilage …

Abstract Background Knee Osteoarthritis (KOA) is a heterogeneous pathology characterized
by a complex and multifactorial nature. It has been hypothesised that these differences are …

Osteoarthritis genetics has been transformed in the past decade through the application of
large-scale genome-wide association scans. So far, over 100 polymorphic DNA variants …

Osteoarthritis (OA) was once defined as a non-inflammatory arthropathy, but it is now well-
recognized that there is a major inflammatory component to this disease. In addition to …

Osteoarthritis is a degenerative disease of joints with destruction of articular cartilage
associated with subchondral bone hypertrophy and inflammation. OA is the leading cause of …

Articular chondrocytes are quiescent, fully differentiated cells responsible for the
homeostasis of adult articular cartilage by maintaining cellular survival functions and the fine …

Mitochondria and mitochondrial DNA (mtDNA) variation are now recognized as important
factors in the development of osteoarthritis (OA). Mitochondria are the energy powerhouses …

Objective In this review, we have highlighted the advances over the past year in genetics,
genomics and epigenetics in the field of osteoarthritis (OA). Methods A literature search of …