DNA mismatch repair
TA Kunkel, DA Erie - Annu. Rev. Biochem., 2005 - annualreviews.org
▪ Abstract DNA mismatch repair (MMR) is an evolutionarily conserved process that corrects
mismatches generated during DNA replication and escape proofreading. MMR proteins also …
mismatches generated during DNA replication and escape proofreading. MMR proteins also …
Postreplicative mismatch repair
J Jiricny - Cold Spring Harbor perspectives in biology, 2013 - cshperspectives.cshlp.org
The mismatch repair (MMR) system detects non-Watson–Crick base pairs and strand
misalignments arising during DNA replication and mediates their removal by catalyzing …
misalignments arising during DNA replication and mediates their removal by catalyzing …
Rate and molecular spectrum of spontaneous mutations in the bacterium Escherichia coli as determined by whole-genome sequencing
Knowledge of the rate and nature of spontaneous mutation is fundamental to understanding
evolutionary and molecular processes. In this report, we analyze spontaneous mutations …
evolutionary and molecular processes. In this report, we analyze spontaneous mutations …
Eukaryotic base excision repair: new approaches shine light on mechanism
WA Beard, JK Horton, R Prasad… - Annual review of …, 2019 - annualreviews.org
Genomic DNA is susceptible to endogenous and environmental stresses that modify DNA
structure and its coding potential. Correspondingly, cells have evolved intricate DNA repair …
structure and its coding potential. Correspondingly, cells have evolved intricate DNA repair …
Determinants of spontaneous mutation in the bacterium Escherichia coli as revealed by whole-genome sequencing
PL Foster, H Lee, E Popodi… - Proceedings of the …, 2015 - National Acad Sciences
A complete understanding of evolutionary processes requires that factors determining
spontaneous mutation rates and spectra be identified and characterized. Using mutation …
spontaneous mutation rates and spectra be identified and characterized. Using mutation …
Constant pH molecular dynamics simulations of nucleic acids in explicit solvent
The nucleosides of adenine and cytosine have p K a values of 3.50 and 4.08, respectively,
and are assumed to be unprotonated under physiological conditions. However, evidence …
and are assumed to be unprotonated under physiological conditions. However, evidence …
[HTML][HTML] MUTYH DNA glycosylase: the rationale for removing undamaged bases from the DNA
E Markkanen, J Dorn, U Hübscher - Frontiers in genetics, 2013 - frontiersin.org
Maintenance of genetic stability is crucial for all organisms in order to avoid the onset of
deleterious diseases such as cancer. One of the many proveniences of DNA base damage …
deleterious diseases such as cancer. One of the many proveniences of DNA base damage …
The Rate and Spectrum of Spontaneous Mutations in Mycobacterium smegmatis, a Bacterium Naturally Devoid of the Postreplicative Mismatch Repair Pathway
Mycobacterium smegmatis is a bacterium that is naturally devoid of known postreplicative
DNA mismatch repair (MMR) homologs, mutS and mutL, providing an opportunity to …
DNA mismatch repair (MMR) homologs, mutS and mutL, providing an opportunity to …
Hypermutable bacteria isolated from humans–a critical analysis
LMC Hall, SK Henderson-Begg - Microbiology, 2006 - microbiologyresearch.org
Hypermutable bacteria of several species have been described among isolates recovered
from humans over the last decade. Interpretation of the literature in this area is complicated …
from humans over the last decade. Interpretation of the literature in this area is complicated …
Determinants of Base-Pair Substitution Patterns Revealed by Whole-Genome Sequencing of DNA Mismatch Repair Defective Escherichia coli
PL Foster, BA Niccum, E Popodi, JP Townes, H Lee… - Genetics, 2018 - academic.oup.com
Proofreading during DNA replication and post-replication mismatch repair are two major
defenses against mutations. Foster et al. and Niccum et al. used mutation accumulation and …
defenses against mutations. Foster et al. and Niccum et al. used mutation accumulation and …