T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

The recent success of cancer immunotherapies has highlighted the benefit of harnessing the
immune system for cancer treatment. Vaccines have a long history of promoting immunity to …

Senescent cell accumulation has been implicated in the pathogenesis of aging-associated
diseases, including cancer. The mechanism that prevents the accumulation of senescent …

Whereas CD4+ T cells conventionally mediate antitumor immunity by providing help to
CD8+ T cells, recent clinical studies have implied an important role for cytotoxic CD4+ T …

CD4+ T cells are critical orchestrators of immune responses against a large variety of
pathogens, including viruses. While multiple CD4+ T cell subtypes and their key …

Cytotoxic T lymphocytes (CTLs) play critical antitumor roles, encompassing diverse subsets
including CD4+, NK, and γδ T cells beyond conventional CD8+ CTLs. However, definitive …

Vaccination remains our main defence against influenza, which causes substantial annual
mortality and poses a serious pandemic threat. Influenza virus evades immunity by rapidly …

The intestinal immune system must tolerate food antigens to avoid allergy, a process
requiring CD4+ T cells. Combining antigenically defined diets with gnotobiotic models, we …

Sjögren's syndrome (SS) is an autoimmune disease characterized by the involvement of
exocrine glands such as the salivary and lacrimal glands. The minor salivary glands, from …

Immunotherapy plays a key role in cancer treatment, however, responses are limited to a
small number of patients. The biological basis for the success of immunotherapy is the …