Heart failure remains a continuing threat to patients with chronic kidney disease (CKD).
Although various heart failure biomarkers have been applied for early detection, diagnosis …

Multiple studies have confirmed that programmed cell death 1/programmed cell death ligand-
1 (PD-1/PD-L1) and immune checkpoint inhibitors (ICIs) targeting PD-1/PD-L1 play pivotal …

Highlights•An aptamer with high affinity, high specificity, and high stability for binding to both
human-derived and rat-derived GDF15 was obtained.• The molecular mechanism and key …

Cardiac fibrosis is associated with non-ischemic dilated cardiomyopathy, increasing its
morbidity and mortality. Cardiac fibroblast is the keystone of fibrogenesis, being activated by …

The majority of acute cardiovascular events (CVE) in patients are caused by occlusive
thrombosis because of rupture or erosion of atherosclerotic plaques. 1 Growth differentiation …

Background Although growth differentiation factor 15 (GDF15) is known to increase with
disease and is associated with low physical performance, the role of GDF15 in normal …

Abstract Growth differentiation factor-15 (GDF-15), also known as macrophage inhibitory
cytokine-1 (MIC-1) or non-steroidal anti-inflammatory drug-activated gene (NAG-1) has been …

Background Stemness, a key component of breast cancer (BC) heterogeneity, is responsible
for chemoresistance. Growth differentiation factor-15 (GDF-15) induces drug resistance and …

Serum GDF15 levels are correlated with multiple neurodegenerative diseases. Few studies
have tested this marker's association with middle-aged cognitive performance over time, and …

OBJECTIVE Coronary artery disease (CAD) is a major challenge in patients with type 2
diabetes (T2D). Coronary computed tomography angiography (CCTA) provides a detailed …