About 10% of women of reproductive age are unable to conceive or carry a pregnancy to
term. Female factors alone account for at least 35% of all infertility cases and comprise a …

The ovarian system comprises vital organs in females and is of great significance for the
maintenance of reproductive potential and endocrine stability. Although complex …

It is well known that female reproduction ability decreases during the forth decade of life due
to age-related changes in oocyte quality and quantity; although the number of women trying …

Advanced maternal age (AMA;> 35 year) is associated with a decline in both ovarian
reserve and oocyte competence. At present, no remedies are available to counteract the …

Producing high-competent oocytes during the in vitro maturation (IVM) is considered a key
step for the success of the in vitro production (IVP) of embryos. One of the known disruptors …

The ovary ages earlier than most other tissues, yet the underlying mechanisms remain
elusive. Here a comprehensive analysis of transcriptomic landscapes in different organs in …

There has been increasing interest in the role of endocannabinoids as critical modulators of
the female reproductive processes. Endocannabinoids are natural ligands of cannabinoid …

Maternal fertility declines irreversibly with aging, and advanced maternal age is mostly
related to impaired oocyte quality. The flavonol compound quercetin is considered to be an …

Premature ovarian insufficiency (POI) is a condition that arises from dysfunction or early
depletion of the ovarian follicle pool accompanied by an earlier-than-normal loss of fertility in …

The mitochondrial DNA (mtDNA) m. 3243A> G mutation is one of the most common
pathogenic mtDNA variants, showing complex genetics, pathogenic molecular mechanisms …