Various types of cells are routinely cryopreserved in modern regenerative and cell-based
medicines. For instance, the oocyte is one of the most demanding cells to be cryopreserved …

The decline of oocyte quality has profound impacts on fertilization, implantation, embryonic
development, and the genetic quality of future generations. One factor that is often ignored …

Ovarian age is classically considered the main cause of female reproductive infertility. In
women, the process proceeds as an ongoing decline in the primordial follicle stockpile and it …

Polycystic ovary syndrome (PCOS) is typically characterized by a polycystic ovarian
morphology, hyperandrogenism, ovulatory dysfunction, and infertility. Furthermore, PCOS …

Premature ovarian insufficiency (POI) is a condition that arises from dysfunction or early
depletion of the ovarian follicle pool accompanied by an earlier-than-normal loss of fertility in …

The NAD+‐dependent sirtuin deacetylase, Sirt1, regulates key transcription factors strongly
implicated in ageing and lifespan. Due to potential confounding effects secondary to loss of …

Background and Purpose As the global fertility rate declines, China has issued two and
three-child policies in the past 10 years. Therefore, this study serves to evaluate fertility …

Although age‐related ovarian failure in female mammals cannot be reversed, recent
strategies have focused on improving reproductive capacity with age, and rapamycin is one …

STUDY QUESTION Could the mitochondrial DNA (mtDNA) content of cumulus granulosa
cells (CGCs) be related to oocyte competence? SUMMARY ANSWER The quality of …

Dietary assessment reports and population surveillance programs show that chronic
exposure to low levels of environmental cadmium (Cd) is inevitable for most people, and …