Targeted protein degradation (TPD) has emerged as a promising therapeutic approach with
potential advantages over traditional occupancy-based inhibitors in terms of dosing, side …

Click chemistry is universally recognized as a powerful strategy for the fast and precise
assembly of diverse building blocks. Targeted Protein Degradation (TPD) is a new …

Ferroptosis is a new form of non-apoptotic programmed cell death. Due to its effectiveness in
cancer treatment, there are increasing studies on the application of nanoparticles based on …

Proteolysis-targeting chimeras or PROTACs are hetero-bifunctional molecules designed to
mediate the disposal of a target protein via recruitment of the ubiquitination–proteasome …

Abstract PROTACs (Proteolysis‐Targeting Chimeras) have emerged as a groundbreaking
class of chemical tools that facilitate the degradation of target proteins by leveraging the …

Proteolysis-targeting chimera (PROTAC) technology is a groundbreaking therapeutic
approach with significant clinical potential for degrading disease-inducing proteins within …

Random difunctionalization of dendrimer surfaces, frequently employed in biological
applications, provides the advantage of dual functional groups through a synthetic pathway …

Proteolysis targeting chimera (PROTAC) technology represents a groundbreaking
development in drug discovery, leveraging the ubiquitin‒proteasome system to specifically …

PROTAC (Proteolysis TArgeting Chimeras) is a promising therapeutic approach for targeted
protein degradation that recruits an E3 ubiquitin ligase to a specific protein of interest (POI) …

Deep penetration and downregulation of heat shock protein (HSP) expression in multimodal
synergistic therapy are promising approaches for curing cancer in clinical trials. However …