Whole blood, as one of the most significant biological fluids, provides critical information for
health management and disease monitoring. Over the past 10 years, advances in …

Recent medical advances have exploited the ability to address a given disease at the
underlying level of transcription and translation. These treatment paradigms utilize nucleic …

MicroRNAs (miRNAs) are small noncoding RNAs that act as master regulators in many
biological processes. miRNAs function mainly by downregulating the expression of their …

Macroautophagy/autophagy is a cellular catabolic process that results in lysosome-
mediated recycling of organelles and protein aggregates, as well as the destruction of …

RNA-based therapies, including RNA molecules as drugs and RNA-targeted small
molecules, offer unique opportunities to expand the range of therapeutic targets. Various …

We perform a large-scale RNA sequencing study to experimentally identify genes that are
downregulated by 25 miRNAs. This RNA-seq dataset is combined with public miRNA target …

Background The therapeutic potential of exosomes derived from stem cells has attracted
increasing interest recently, because they can exert similar paracrine functions of stem cells …

Abnormal expression of miRNAs is often detected in various human cancers. DNAzyme
machines combined with gold nanoparticles (AuNPs) hold promise for detecting specific …

Comprehensive databases of microRNA–disease associations are continuously demanded
in biomedical researches. The recently launched version 3.0 of Human MicroRNA Disease …

While the number of human miRNA candidates continuously increases, only a few of them
are completely characterized and experimentally validated. Toward determining the total …