The relationships between inflammation and cancer are varied and complex. An important
connection linking inflammation to cancer development is DNA damage. During …

Alkylating agents constitute a major class of frontline chemotherapeutic drugs that inflict
cytotoxic DNA damage as their main mode of action, in addition to collateral mutagenic …

The AlkB family of Fe (II)-and α-ketoglutarate-dependent dioxygenases is a class of
ubiquitous direct reversal DNA repair enzymes that remove alkyl adducts from nucleobases …

The genomic integrity of every organism is constantly challenged by endogenous and
exogenous DNA-damaging factors. Mutagenic agents cause reduced stability of plant …

Regardless of their targets and modes of action, subinhibitory concentrations of antibiotics
can have an impact on cell physiology and trigger a large variety of cellular responses in …

DNA is continuously attacked by reactive species that can affect its structure and function
severely. Structural modifications to DNA mainly arise from modifications in its bases that …

Alkylating agents have been used since the 60ties in brain cancer chemotherapy. Their
target is the DNA and, although the DNA of normal and cancer cells is damaged …

Hazardous chemicals in the environment and diet or their electrophilic metabolites can form
adducts with genomic DNA, which can lead to mutations and the initiation of cancer. In …

O 6-Alkylguanine-DNA alkyltransferase (AGT) is a widely distributed, unique DNA repair
protein that acts as a single agent to directly remove alkyl groups located on the O 6-position …

DNA damage is induced by many factors, some of which naturally occur in the environment.
Because of their sessile nature, plants are especially exposed to unfavorable conditions …