Phenytoin (PHT) is an antiepileptic drug widely used in the treatment of focal epilepsy and
status epilepticus, and effective in controlling focal seizures with and without tonic–clonic …

Drug-resistant epilepsy affects approximately one-third of the patients with epilepsy. The
pharmacoresistant condition in epilepsy is mainly explained by six hypotheses. In addition …

Epilepsy is a common, serious neurological disorder worldwide. Although this disease can
be successfully treated in most cases, not all patients respond favorably to medical …

Epilepsy refers to a common chronic neurological disorder that affects all age groups.
Unfortunately, antiepileptic drugs are ineffective in about one-third of patients. The complex …

Epilepsy is one of the oldest known neurological disorders and is characterized by recurrent
seizure activity. It has a high incidence rate, affecting a broad demographic in both …

Epilepsy is a common neurological problem, and there is a genetic basis in almost 50% of
people with epilepsy. The diagnosis of genetic epilepsies makes the patient assured of the …

Objective Epilepsy is a neurologically based disease. Literature data indicate a certain
association between the polymorphism of these genes, which participate in the metabolism …

Epilepsy is a major global issue. Epilepsy patients are treated with AED (antiepileptic drugs).
Interindividual variability in drug response has been documented in several studies. The …

Sodium channel alpha subunit type 1 (SCN1A) is voltage gated ion channel which plays
critical role in membrane excitability. A common SCN1A IVS5-91G> A (rs3812718) allele …

ABSTRACT Background and Objective: Epilepsy, the most common neurological disorder,
has treatment failure rate of 20 to 25%. Inter-individual variability in drug response can be …