Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells
K Blaschke, KT Ebata, MM Karimi, JA Zepeda-Martínez… - Nature, 2013 - nature.com
DNA methylation is a heritable epigenetic modification involved in gene silencing,
imprinting, and the suppression of retrotransposons. Global DNA demethylation occurs in …
imprinting, and the suppression of retrotransposons. Global DNA demethylation occurs in …
[HTML][HTML] Dynamic readers for 5-(hydroxy) methylcytosine and its oxidized derivatives
CG Spruijt, F Gnerlich, AH Smits, T Pfaffeneder… - Cell, 2013 - cell.com
Tet proteins oxidize 5-methylcytosine (mC) to generate 5-hydroxymethyl (hmC), 5-formyl
(fC), and 5-carboxylcytosine (caC). The exact function of these oxidative cytosine bases …
(fC), and 5-carboxylcytosine (caC). The exact function of these oxidative cytosine bases …
[HTML][HTML] The dynamics of genome-wide DNA methylation reprogramming in mouse primordial germ cells
Genome-wide DNA methylation reprogramming occurs in mouse primordial germ cells
(PGCs) and preimplantation embryos, but the precise dynamics and biological outcomes are …
(PGCs) and preimplantation embryos, but the precise dynamics and biological outcomes are …
[HTML][HTML] Understanding the relationship between DNA methylation and histone lysine methylation
DNA methylation acts as an epigenetic modification in vertebrate DNA. Recently it has
become clear that the DNA and histone lysine methylation systems are highly interrelated …
become clear that the DNA and histone lysine methylation systems are highly interrelated …
A unique regulatory phase of DNA methylation in the early mammalian embryo
DNA methylation is highly dynamic during mammalian embryogenesis. It is broadly
accepted that the paternal genome is actively depleted of 5-methylcytosine at fertilization …
accepted that the paternal genome is actively depleted of 5-methylcytosine at fertilization …
Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine
Mouse primordial germ cells (PGCs) undergo sequential epigenetic changes and genome-
wide DNA demethylation to reset the epigenome for totipotency. Here, we demonstrate that …
wide DNA demethylation to reset the epigenome for totipotency. Here, we demonstrate that …
[HTML][HTML] Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain
Cytosine methylation is the major covalent modification of mammalian genomic DNA and
plays important roles in transcriptional regulation. The molecular mechanism underlying the …
plays important roles in transcriptional regulation. The molecular mechanism underlying the …
Epigenetic reprogramming in plant and animal development
S Feng, SE Jacobsen, W Reik - Science, 2010 - science.org
Epigenetic modifications of the genome are generally stable in somatic cells of multicellular
organisms. In germ cells and early embryos, however, epigenetic reprogramming occurs on …
organisms. In germ cells and early embryos, however, epigenetic reprogramming occurs on …
Epigenetic reprogramming enables the transition from primordial germ cell to gonocyte
Gametes are highly specialized cells that can give rise to the next generation through their
ability to generate a totipotent zygote. In mice, germ cells are first specified in the developing …
ability to generate a totipotent zygote. In mice, germ cells are first specified in the developing …
Uncovering the role of 5-hydroxymethylcytosine in the epigenome
Just over 2 years ago, TET1 was found to catalyse the oxidation of 5-methylcytosine, a well-
known epigenetic mark, into 5-hydroxymethylcytosine in mammalian DNA. The exciting …
known epigenetic mark, into 5-hydroxymethylcytosine in mammalian DNA. The exciting …