During the past decade, cancer stem cells (CSCs) have been increasingly identified in many
malignancies. Although the origin and plasticity of these cells remain controversial, tumour …

Covering: up to the end of 2010 Saponins are polar molecules that consist of a triterpene or
steroid aglycone with one or more sugar chains. They are one of the most numerous and …

Activation of Wnt signaling through β-catenin/TCF complexes is a key event in the
development of various tumors, in particular colorectal and liver tumors. Wnt signaling is …

Inherited and somatic mutations in the adenomatous polyposis coli occur in most colon
cancers, leading to activation of β-catenin-responsive genes. To identify small molecule …

Current animal and 2‐D cell culture models employed in metastasis research and drug
discovery remain poor mimics of human cancer physiology. Here we describe a “metastasis …

Misregulated β-catenin responsive transcription (CRT) has been implicated in the genesis of
various malignancies, including colorectal carcinomas, and it is a key therapeutic target in …

Purpose: We examined the effects of the phytochemical resveratrol in six human cancer cell
lines (MCF7, SW480, HCE7, Seg-1, Bic-1, and HL60). Experimental Design and Results …

Squamous cell carcinoma of the oral tongue (SCCOT) is one of the most prevalent tumors of
the head and neck region. Despite advances in treatment, the survival of patients with …

Invasion causes cancer malignancy. We review recent data about cellular and molecular
mechanisms of invasion, focusing on cross-talk between the invaders and the host. Cancer …

Hepatocellular carcinoma (HCC) is one of the most fatal human malignancies, but the
molecular mechanisms of hepatocarcinogenesis remain unclear. Although p53 mutations …