Epigallocatechin 3-gallate: From green tea to cancer therapeutics
Abstract Epigallocatechin 3-gallate (EGCG) possesses various biological functions,
including anti-cancer and anti-inflammatory properties. EGCG is an abundant polyphenolic …
including anti-cancer and anti-inflammatory properties. EGCG is an abundant polyphenolic …
Targeting STAT3 signaling pathway in cancer by agents derived from Mother Nature
CD Mohan, S Rangappa, HD Preetham… - Seminars in cancer …, 2022 - Elsevier
Signal transducer and activator of transcription (STAT) proteins are latent transcription
factors that reside in the cytoplasm of several types of cells. In canonical signaling, upon …
factors that reside in the cytoplasm of several types of cells. In canonical signaling, upon …
[HTML][HTML] Cancer preventive activities of tea catechins
CS Yang, H Wang - Molecules, 2016 - mdpi.com
Catechins are widely occurring in our diet and beverages. The cancer-preventive activities
of catechins have been extensively studied. Of these,(−)-epigallocatechin-3-gallate (EGCG) …
of catechins have been extensively studied. Of these,(−)-epigallocatechin-3-gallate (EGCG) …
[HTML][HTML] Bax/Bcl-2 cascade is regulated by the EGFR pathway: Therapeutic targeting of non-small cell lung cancer
Non-small cell lung carcinoma (NSCLC) comprises 80%–85% of lung cancer cases. EGFR
is involved in several cancer developments, including NSCLC. The EGFR pathway …
is involved in several cancer developments, including NSCLC. The EGFR pathway …
[HTML][HTML] B cell lymphoma 2: a potential therapeutic target for cancer therapy
Defects in the apoptosis mechanism stimulate cancer cell growth and survival. B cell
lymphoma 2 (Bcl-2) is an anti-apoptotic molecule that plays a central role in apoptosis. Bcl-2 …
lymphoma 2 (Bcl-2) is an anti-apoptotic molecule that plays a central role in apoptosis. Bcl-2 …
Inhibiting STAT3 signaling pathway by natural products for cancer prevention and therapy: In vitro and in vivo activity and mechanisms of action
J Yang, L Wang, X Guan, JJ Qin - Pharmacological Research, 2022 - Elsevier
Signal transducer and activator of transcription 3 (STAT3) plays a critical role in signal
transmission from the plasma membrane to the nucleus, regulating the expression of genes …
transmission from the plasma membrane to the nucleus, regulating the expression of genes …
Epigallocatechin gallate and mitochondria—a story of life and death
Epigallocatechin gallate (EGCG) is a flavonoid belonging to the chemical class of falvan-3-
ols (catechins) esterified with gallic acid. It is the main catechin found in green tea (Camellia …
ols (catechins) esterified with gallic acid. It is the main catechin found in green tea (Camellia …
[HTML][HTML] Green tea and benign gynecologic disorders: A new trick for an old beverage?
Green tea is harvested from the tea plant Camellia sinensis and is one of the most widely
consumed beverages worldwide. It is richer in antioxidants than other forms of tea and has a …
consumed beverages worldwide. It is richer in antioxidants than other forms of tea and has a …
Tea polyphenol EGCG inhibited colorectal-cancer-cell proliferation and migration via downregulation of STAT3
KW Luo, J Xia, BH Cheng, HC Gao… - Gastroenterology …, 2021 - academic.oup.com
Background Green tea is a popular beverage worldwide and epigallocatechin-3-gallate
(EGCG) is the most bioactive polyphenol in green tea. Our study aims to investigate the anti …
(EGCG) is the most bioactive polyphenol in green tea. Our study aims to investigate the anti …
Redox and other biological activities of tea catechins that may affect health: Mechanisms and unresolved issues
The beneficial health effects of green tea have been attributed to tea catechins. However,
the molecular mechanisms of action, especially those in vivo, remain unclear. This article …
the molecular mechanisms of action, especially those in vivo, remain unclear. This article …