Autophagy is an evolutionarily conserved process regulating cellular homeostasis via
digestion of dysfunctional proteins and whole cellular organelles by mechanisms, involving …

Machado-Joseph disease (MJD) is a fatal neurodegenerative disorder clinically
characterized by prominent ataxia. It is caused by an expansion of a CAG trinucleotide in …

Becn1/Beclin-1 is a core component of the class III phosphatidylinositol 3-kinase required for
autophagosome formation and vesicular trafficking. Although Becn1 has been implicated in …

The toxicity of synthetic pyrethroids has garnered attention, and studies have revealed that
pyrethroids promote fat accumulation and lead to obesity in mice. Nevertheless, the effect of …

Aflatoxin M1 (AFM1) is the only mycotoxin with maximum residue limit in milk, which may
result in serious human diseases. On the contrary, lactoferrin (Lf) is an active protein with …

Caffeine has been shown to directly increase fatty acid oxidation, in part, by promoting
mitochondrial biogenesis. Mitochondrial biogenesis is often coupled with mitophagy, the …

Silkie chicken, an important chicken breed with high medicinal and nutritional value, has a
long history of being used as a dietary supplement in China. However, the compounds with …

Autophagy is crucial for cell survival, development, division, and homeostasis. The
mammalian target of rapamycin (mTOR), which is the foremost negative controller of …

We recently demonstrated that a small subset of cells in FLT3-mutated acute myeloid
leukemia (AML) cell lines exhibit SORE6 reporter activity and cancer stem-like features …

Dysregulated lipolysis is a risk factor contributing to metabolic diseases and autophagy is
known to be important in lipolysis. CTCF is involved in diverse cellular processes including …