Adults maintain tissue-specific stem cells through niche signals. A model for niche function is
the Drosophila melanogaster testis, where a small cluster of cells called the hub produce …

Epithelial cells are characterized by apical-basal polarity. Intrinsic factors underlying apical-
basal polarity are crucial for tissue homeostasis and have often been identified to be tumor …

Bone morphogenetic protein (BMP) pathways control an array of developmental and
homeostatic events, and must themselves be exquisitely controlled. Here, we identify …

The dynamics of host–parasite interactions can change dramatically over the course of a
chronic infection as the internal (physiological) and external (environmental) conditions of …

Abstract Hedgehog (Hh) and Bone Morphogenetic Proteins (BMPs) pattern the developing
Drosophila wing by functioning as short-and long-range morphogens, respectively. Here, we …

The cellular response to the Drosophila BMP 2/4-like ligand Decapentaplegic (DPP) serves
as one of the best-studied models for understanding the long-range control of tissue growth …

As the genetic bases to variation in anoxia tolerance are poorly understood, we used the
Drosophila Genetics Reference Panel (DGRP) to conduct a genome-wide association study …

BMP signaling responses are refined by distinct secreted and intracellular antagonists in
different cellular and temporal contexts. Here, we show that the nuclear LEM-domain protein …

Neurotrophism, structural plasticity, learning and long-term memory in mammals critically
depend on neurotrophins binding Trk receptors to activate tyrosine kinase (TyrK) signaling …

Genomes of metazoan organisms possess a large number of genes encoding cell surface
and secreted (CSS) proteins that carry out crucial functions in cell adhesion and …