Current medication for anxiety disorders is suboptimal in terms of efficiency and tolerability,
highlighting the need for improved drug treatments. In this review an overview of drugs …

Depression is apparently the most common psychiatric disease among the mood disorders
affecting about 10% of the adult population. The etiology and pathogenesis of depression …

Evidence supports the observational associations of gut microbiota with a variety of
psychiatric disorders, but the causal nature of such associations remains obscure. Aiming to …

We interrogate the joint genetic architecture of 11 major psychiatric disorders at
biobehavioral, functional genomic and molecular genetic levels of analysis. We identify four …

Objective: Anxiety disorders are common and often disabling. The goal of this study was to
examine the genetic architecture of anxiety disorders and anxiety symptoms, which are also …

Importance Growing evidence suggests that prescription opioid use affects depression and
anxiety disorders; however, observational studies are subject to confounding, making causal …

Local genetic correlation quantifies the genetic similarity of complex traits in specific
genomic regions. However, accurate estimation of local genetic correlation remains …

Depression and anxiety are highly prevalent and comorbid psychiatric traits that cause
considerable burden worldwide. Here we use factor analysis and genomic structural …

Background: Depression and anxiety are two mental disorders that are often comorbid.
However, the associations of long-term air pollution exposure with depression and anxiety …

Noncoding variants of presumed regulatory function contribute to the heritability of
neuropsychiatric disease. A total of 2,221 noncoding variants connected to risk for ten …