Obesity: epidemiology, pathophysiology, and therapeutics

X Lin, H Li - Frontiers in endocrinology, 2021 - frontiersin.org
Obesity is a complex multifactorial disease that accumulated excess body fat leads to
negative effects on health. Obesity continues to accelerate resulting in an unprecedented …

[HTML][HTML] Childhood and adolescent obesity: a review

AR Kansra, S Lakkunarajah, MS Jay - Frontiers in pediatrics, 2021 - frontiersin.org
Obesity is a complex condition that interweaves biological, developmental, environmental,
behavioral, and genetic factors; it is a significant public health problem. The most common …

Clinical management and treatment of obesity in China

Q Zeng, N Li, XF Pan, L Chen, A Pan - The lancet Diabetes & …, 2021 - thelancet.com
China has one of the largest populations with obesity in the world, and obesity has become
a major challenge for the country's health-care system. Current guidelines for obesity …

Genetics and epigenetics in obesity

K Rohde, M Keller, L la Cour Poulsen, M Blüher… - Metabolism, 2019 - Elsevier
Obesity is among the most threatening health burdens worldwide and its prevalence has
markedly increased over the last decades. Obesity maybe considered a heritable trait …

Genetics of obesity: what we have learned over decades of research

C Bouchard - Obesity, 2021 - Wiley Online Library
There is a genetic component to human obesity that accounts for 40% to 50% of the
variability in body weight status but that is lower among normal weight individuals (about …

Efficacy and safety of setmelanotide, an MC4R agonist, in individuals with severe obesity due to LEPR or POMC deficiency: single-arm, open-label, multicentre, phase …

K Clément, E van den Akker, J Argente… - The lancet Diabetes & …, 2020 - thelancet.com
Background The melanocortin 4 receptor (MC4R), a component of the leptin–melanocortin
pathway, plays a part in bodyweight regulation. Severe early-onset obesity can be caused …

[HTML][HTML] Genetic and epigenetic causes of obesity

VV Thaker - Adolescent medicine: state of the art reviews, 2017 - ncbi.nlm.nih.gov
Obesity is a complex, heritable trait influenced by the interplay of genetics, epigenetics,
metagenomics and the environment. With the increasing access to high precision diagnostic …

The pathogenesis of obesity

SM Oussaada, KA Van Galen, MI Cooiman… - Metabolism, 2019 - Elsevier
Body fat mass increases when energy intake exceeds energy expenditure. In the long term,
a positive energy balance will result in obesity. The worldwide prevalence of obesity has …

Diagnosis, treatment and prevention of pediatric obesity: consensus position statement of the Italian Society for Pediatric Endocrinology and Diabetology and the …

G Valerio, C Maffeis, G Saggese, MA Ambruzzi… - Italian journal of …, 2018 - Springer
Abstract The Italian Consensus Position Statement on Diagnosis, Treatment and Prevention
of Obesity in Children and Adolescents integrates and updates the previous guidelines to …

Effect of setmelanotide, a melanocortin‐4 receptor agonist, on obesity in Bardet‐Biedl syndrome

R Haws, S Brady, E Davis, K Fletty… - Diabetes, Obesity …, 2020 - Wiley Online Library
Aim To report an analysis of~ 1 year of setmelanotide treatment for obesity and hunger, as
well as metabolic and cardiac outcomes, in individuals with Bardet‐Biedl syndrome (BBS) …