Objective To determine the prevalence of hypermetabolism, relative to body composition, in
amyotrophic lateral sclerosis (ALS) and its relationship with clinical features of disease and …

The motor unit comprises the anterior horn cell, its axon, and the muscle fibers that it
innervates. Although the true number of motor units is unknown, the number of motor units …

Objective Clinical trials in amyotrophic lateral sclerosis (ALS) continue to rely on survival or
functional scales as endpoints, despite the emergence of quantitative biomarkers …

Increasing evidence shows that disease spreading in amyotrophic lateral sclerosis (ALS)
follows a preferential pattern with more frequent involvement of contiguous regions from the …

Ghrelin is a gut hormone best known for its role in regulating appetite and stimulating the
secretion of the anabolic hormone growth hormone (GH). However, there is considerable …

Objective To investigate the relationship between serum levels of the neuroaxonal
degeneration biomarker neurofilament light chain (NFL) and phenotype in ALS. Materials …

Objective To compare serum levels of the astrocyte biomarker glial fibrillary acidic protein
(GFAP) in patients with amyotrophic lateral sclerosis (ALS) and neurologically healthy …

Introduction Amyotrophic lateral sclerosis (ALS) individuals carrying the hexanucleotide
repeat expansion (HRE) in the C9orf72 gene (C9Pos) have been described as presenting …

Background Currently, there is a lack of knowledge concerning where the pathological
process starts and how the neurodegeneration spreads during the course of amyotrophic …

Background and purpose This study sought to evaluate the relationship of progressive
corticospinal tract (CST) degeneration with survival in patients with amyotrophic lateral …