Intermittent hypoxia (IH) is thought to be responsible for many of the long‐term
cardiovascular consequences associated with obstructive sleep apnoea (OSA) …

The regulation of cerebral blood flow (CBF) is a complex process that is altered significantly
with altitude exposure. Acute exposure produces a marked increase in CBF, in proportion to …

Investigations into the blood oxygenation level-dependent (BOLD) functional MRI signal
have used respiratory challenges with the aim of probing cerebrovascular physiology. Such …

We determined the ventilatory, cardiovascular and cerebral tissue oxygen response to two
protocols of normobaric, isocapnic, intermittent hypoxia. Subjects (n= 18, male) were …

Reduction of aerobic exercise performance observed under hypoxic conditions is mainly
attributed to altered muscle metabolism due to impaired O2 delivery. It has been recently …

Rationale: Acute mountain sickness (AMS) may affect individuals who (rapidly) ascend to
altitudes higher than 2,000–3,000 m. A more serious consequence of rapid ascent may be …

The aim of the present study was to examine changes in cerebral metabolism by magnetic
resonance imaging of healthy subjects during inhalation of 10% O2 hypoxic air. Hypoxic …

We compared the integrated cardiovascular and autonomic responses to hypercapnia and
hypoxia to test the hypothesis that these stimuli differentially affect muscle sympathetic nerve …

Both hypoxia and carbon dioxide increase cerebral blood flow (CBF), and their effective
interaction is currently thought to be additive. Our objective was to test this hypothesis. Eight …

The effects of submaximal and maximal exercise on cerebral perfusion were assessed using
a portable, recumbent cycle ergometer in nine unacclimatized subjects ascending to 5,260 …