Chronic wounds

V Falanga, RR Isseroff, AM Soulika… - Nature Reviews …, 2022 - nature.com
Chronic wounds are characterized by their inability to heal within an expected time frame
and have emerged as an increasingly important clinical problem over the past several …

Chronic wounds: Current status, available strategies and emerging therapeutic solutions

K Las Heras, M Igartua, E Santos-Vizcaino… - Journal of controlled …, 2020 - Elsevier
In the past decades, adequate and well-planned management of chronic wounds has
reached an elevated importance to improve human's quality of life and extend life …

Skin tissue engineering: wound healing based on stem-cell-based therapeutic strategies

A Nourian Dehkordi, F Mirahmadi Babaheydari… - Stem cell research & …, 2019 - Springer
Normal wound healing is a dynamic and complex multiple phase process involving
coordinated interactions between growth factors, cytokines, chemokines, and various cells …

Emerging treatment strategies in wound care

M Mirhaj, S Labbaf, M Tavakoli… - International Wound …, 2022 - Wiley Online Library
Wound healing is a complex process in tissue regeneration through which the body
responds to the dissipated cells as a result of any kind of severe injury. Diabetic and non …

Engineering bioactive scaffolds for skin regeneration

M Hosseini, A Shafiee - Small, 2021 - Wiley Online Library
Large skin wounds pose a major clinical challenge. Scarcity of donor site and postsurgical
scarring contribute to the incomplete or partial loss of function and aesthetic concerns in skin …

Applications of hydrogel‐based delivery systems in wound care and treatment: An up‐to‐date review

G Divyashri, RV Badhe, B Sadanandan… - Polymers for …, 2022 - Wiley Online Library
Natural wound healing is a highly complex and regulated process. Disruption and barriers to
cellular and tissue repair processes contributes to impaired wound healing, including …

MSCs and their exosomes: a rapidly evolving approach in the context of cutaneous wounds therapy

F Marofi, KI Alexandrovna, R Margiana… - Stem Cell Research & …, 2021 - Springer
Currently, mesenchymal stem/stromal stem cell (MSC) therapy has become a promising
option for accelerating cutaneous wound healing. In vivo reports have outlined the robust …

Activated mesenchymal stem cells interact with antibiotics and host innate immune responses to control chronic bacterial infections

V Johnson, T Webb, A Norman, J Coy, J Kurihara… - Scientific reports, 2017 - nature.com
Chronic bacterial infections associated with biofilm formation are often difficult to resolve
without extended courses of antibiotic therapy. Mesenchymal stem cells (MSC) exert …

Engineered delivery strategies for enhanced control of growth factor activities in wound healing

Y Niu, Q Li, Y Ding, L Dong, C Wang - Advanced drug delivery reviews, 2019 - Elsevier
Growth factors (GFs) are versatile signalling molecules that orchestrate the dynamic, multi-
stage process of wound healing. Delivery of exogenous GFs to the wound milieu to mediate …

Secretome of adipose tissue-derived stem cells (ASCs) as a novel trend in chronic non-healing wounds: an overview of experimental in vitro and in vivo studies and …

F Lombardi, P Palumbo, FR Augello… - International journal of …, 2019 - mdpi.com
Wound healing is a complex process with a linear development that involves many actors in
a multistep timeline commonly divided into four stages: Hemostasis, inflammation …