Drosophila glia: Few cell types and many conserved functions

K Yildirim, J Petri, R Kottmeier, C Klämbt - Glia, 2019 - Wiley Online Library
Glial cells constitute without any dispute an essential element in providing an efficiently
operating nervous system. Work in many labs over the last decades has demonstrated that …

A genetic, genomic, and computational resource for exploring neural circuit function

FP Davis, A Nern, S Picard, MB Reiser, GM Rubin… - Elife, 2020 - elifesciences.org
The anatomy of many neural circuits is being characterized with increasing resolution, but
their molecular properties remain mostly unknown. Here, we characterize gene expression …

The glia of the adult Drosophila nervous system

MC Kremer, C Jung, S Batelli, GM Rubin, U Gaul - Glia, 2017 - Wiley Online Library
Glia play crucial roles in the development and homeostasis of the nervous system. While the
GLIA in the Drosophila embryo have been well characterized, their study in the adult …

Unraveling Novel Mechanisms of Neurodegeneration Through a Large-Scale Forward Genetic Screen in Drosophila

SL Deal, S Yamamoto - Frontiers in genetics, 2019 - frontiersin.org
Neurodegeneration is characterized by progressive loss of neurons. Genetic and
environmental factors both contribute to demise of neurons, leading to diverse devastating …

Glia relay differentiation cues to coordinate neuronal development in Drosophila

VM Fernandes, Z Chen, AM Rossi, J Zipfel, C Desplan - Science, 2017 - science.org
Neuronal birth and specification must be coordinated across the developing brain to
generate the neurons that constitute neural circuits. We used the Drosophila visual system to …

A Drosophila glial cell atlas reveals a mismatch between transcriptional and morphological diversity

I Lago-Baldaia, M Cooper, A Seroka, C Trivedi… - PLoS …, 2023 - journals.plos.org
Morphology is a defining feature of neuronal identity. Like neurons, glia display diverse
morphologies, both across and within glial classes, but are also known to be …

The role of glia clocks in the regulation of sleep in Drosophila melanogaster

M Damulewicz, B Doktór, Z Baster… - Journal of …, 2022 - Soc Neuroscience
In Drosophila melanogaster, the pacemaker located in the brain plays the main role in
maintaining circadian rhythms; however, peripheral oscillators including glial cells, are also …

Physiological and pathological roles of FATP-mediated lipid droplets in Drosophila and mice retina

DM Van Den Brink, A Cubizolle, G Chatelain… - PLoS …, 2018 - journals.plos.org
Increasing evidence suggests that dysregulation of lipid metabolism is associated with
neurodegeneration in retinal diseases such as age-related macular degeneration and in …

A novel Drosophila injury model reveals severed axons are cleared through a Draper/MMP-1 signaling cascade

MD Purice, A Ray, EJ Münzel, BJ Pope, DJ Park… - Elife, 2017 - elifesciences.org
Neural injury triggers swift responses from glia, including glial migration and phagocytic
clearance of damaged neurons. The transcriptional programs governing these complex …

Organization of projection neurons and local neurons of the primary auditory center in the fruit fly Drosophila melanogaster

E Matsuo, H Seki, T Asai, T Morimoto… - Journal of …, 2016 - Wiley Online Library
Acoustic communication between insects serves as an excellent model system for analyzing
the neuronal mechanisms underlying auditory information processing. The detailed …