Abstract Phosphatidylinositol 3-kinases (PI3Ks) are a family of intracellular signal transducer
enzymes that can attach a phosphate group to the 3'-hydroxyl of the inositol moiety of …

Chronic lymphocytic leukemia (CLL) is the most common leukemia affecting adults. CLL
results due to uncontrolled accumulation of B lymphocytes in the body with the clinical …

Background Chronic lymphocytic leukemia (CLL) is a heterogeneous B-cell malignancy that
lacks specific biomarkers and drug targets. Competing endogenous RNAs (ceRNAs) play …

The Patient Similarity Network paradigm implies modeling the similarity between patients
based on specific data. The similarity can summarize patients' relationships from high …

The analysis of the immunogenetic background of multiple myeloma (MM) has proven key to
understanding disease ontogeny. However, limited information is available regarding the …

Small nucleolar RNAs (snoRNAs) are responsible for post-transcriptional modification of
ribosomal RNAs, transfer RNAs and small nuclear RNAs, and thereby have important …

Aims Despite the development of therapeutic strategies for chronic lymphocytic leukemia
(CLL), most patients remain incurable, relapse, or refractory to current treatments, indicating …

Histone methyltransferases (HMTs) are enzymes that regulate histone methylation and play
an important role in controlling transcription by altering the chromatin structure. Aberrant …

Chronic lymphocytic leukemia (CLL) is a widespread type of leukemia that predominantly
targets B lymphocytes, undermining the balance between cell proliferation and apoptosis. In …

It has been known for decades that the incidence of chronic lymphocytic leukemia (CLL) is
significantly lower in Asia than in Western countries, but the reason responsible for this …