Hutchinson–Gilford progeria syndrome (HGPS or progeria) is typically caused by a
dominant-negative C• G-to-T• A mutation (c. 1824 C> T; p. G608G) in LMNA, the gene that …

Summary X-linked Dystonia-Parkinsonism (XDP) is a Mendelian neurodegenerative
disease that is endemic to the Philippines and is associated with a founder haplotype. We …

X-linked dystonia-parkinsonism (XDP) is a neurodegenerative disease associated with an
antisense insertion of a SINE-VNTR-Alu (SVA)-type retrotransposon within an intron of …

Daptomycin is a 13 amino acid, cyclic lipopeptide produced by a non-ribosomal peptide
synthetase (NRPS) mechanism in Streptomyces roseosporus. A 128 kb region of S …

Background Aeromonas salmonicida subsp. salmonicida is a Gram-negative bacterium that
is the causative agent of furunculosis, a bacterial septicaemia of salmonid fish. While other …

Abstract Full-length RecE and RecT from Rac prophage mediate highly efficient linear–
linear homologous recombination that can be used to clone large DNA regions directly from …

A 30-fold redundant human bacterial artificial chromosome (BAC) library with a large
average insert size (178 kb) has been constructed to provide the intermediate substrate for …

Bacterial artificial chromosome (BAC) and P1-derived artificial chromosome (PAC) libraries
providing a combined 33-fold representation of the murine genome have been constructed …

Serotonin (5HT) is a critical modulator of neural circuits that support diverse behaviors and
physiological processes, and multiple lines of evidence implicate abnormal serotonergic …

The widely used, very-low-copy BAC (bacterial artificial chromosome) vectors are the
mainstay of present genomic research. The principal advantage of BACs is the high stability …