Diabetes mellitus (DM) is a complex metabolic disease with many specifically related
complications. Early diagnosis of this disease could prevent the progression to overt disease …

Diabetes is an age-related chronic health condition and a major public health concern.
Diabetes is one of the significant causes of morbidity and mortality and a major contributing …

Background & Aims Gallstones (cholelithiasis) constitute a major health burden with high
costs related to surgical removal of the gallbladder (cholecystectomy), generally indicated …

The incidence of early-onset colorectal cancer (EO-CRC) is rising and is poorly understood.
Lifestyle factors and altered genetic background possibly contribute. Here, we performed …

Background: Type 2 diabetes (T2D) is a metabolic condition induced by insulin resistance
and pancreatic beta cell dysfunction. MicroRNAs (miRNAs) have biological significance …

Genome‐wide association studies (GWAS) have facilitated a substantial and rapid increase
in the number of confirmed genetic susceptibility variants for complex diseases …

Patients with HNF1A variants may develop liver steatosis, while the underlying mechanism
is still unclear. Here, we established a mouse model carrying the dominant-negative HNF1α …

Maturity-Onset Diabetes of the Young (MODY) is a rare form of diabetes which affects
between 1% and 5% of diagnosed diabetes cases. Clinical characterizations of MODY …

Despite the exact biological role of HNF1 homolog A (HNF1A) in the regulatory mechanism
of glioblastoma (GBM), the molecular mechanism, especially the downstream regulation as …

Genetic studies have identified numerous loci associated with type 2 diabetes (T2D), but the
functional roles of many loci remain unexplored. Here, we engineered isogenic knockout …