Somatostatin, also known as somatotropin-release inhibitory factor, is a cyclopeptide that
exerts potent inhibitory actions on hormone secretion and neuronal excitability. Its …

G protein‐coupled receptors (GPCRs) and heterotrimeric G proteins play central roles in a
diverse array of cellular processes. As such, dysregulation of GPCRs and their coupled …

Substantial advances have been made recently in the pathobiology of pituitary tumors.
Similar to many other endocrine tumors, over the last few years we have recognized the role …

Context: Familial isolated pituitary adenoma (FIPA) due to aryl hydrocarbon receptor
interacting protein (AIP) gene mutations is an autosomal dominant disease with incomplete …

Recently, a number of novel genetic alterations have been identified that predispose
individuals to pituitary adenomas. Clinically relevant pituitary adenomas are relatively …

Objective Most pituitary tumours occur sporadically without a genetically identifiable
germline abnormality, a small but increasing proportion present with a genetic defect that …

The genetic landscape of pituitary adenomas (PAs) is diverse and many of the identified
cases remain of unclear pathogenetic mechanism. Germline genetic defects account for a …

The molecular mechanisms leading to aryl hydrocarbon receptor interacting protein (AIP)
mutation-induced aggressive, young-onset growth hormone-secreting pituitary tumors are …

Growth hormone (GH)-secreting pituitary tumours represent the most genetically determined
pituitary tumour type. This is true both for germline and somatic mutations. Germline …

Pituitary adenomas (PAs) can be classified as non-secreting adenomas, somatotroph
adenomas, corticotroph adenomas, lactotroph adenomas, and thyrotroph adenomas …