FXR agonists for MASH therapy: Lessons and perspectives from obeticholic acid

K Wang, Y Zhang, G Wang, H Hao… - Medicinal Research …, 2024 - Wiley Online Library
Nonalcoholic fatty liver disease, also called metabolic dysfunction‐associated steatotic liver
disease, is the most common liver disease worldwide and has no approved …

Therapeutic implications of impaired nuclear receptor function and dysregulated metabolism in Wilson's disease

CR Wooton-Kee - Pharmacology & Therapeutics, 2023 - Elsevier
Copper is an essential trace element that is required for the activity of many enzymes and
cellular processes, including energy homeostasis and neurotransmitter biosynthesis; …

AICAR Ameliorates Non-Alcoholic Fatty Liver Disease via Modulation of the HGF/NF-κB/SNARK Signaling Pathway and Restores Mitochondrial and Endoplasmic …

DH Zineldeen, NM Tahoon, NI Sarhan - International Journal of …, 2023 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is a global health problem characterized by
altered lipid and redox homeostasis, mitochondrial dysfunction, and endoplasmic reticulum …

Integration of transcriptomics and metabonomics revealed the protective effects of hemp seed oil against methionine–choline-deficient diet-induced non-alcoholic …

M Gong, H Lu, L Li, M Feng, Z Zou - Food & Function, 2023 - pubs.rsc.org
Non-alcoholic steatohepatitis (NASH) is a chronic liver disease with few therapeutic options
available currently. Hemp seed oil extracted from the seeds of hemp (Cannabis sativa L.) …

Pharmaceutical Strategies to Improve Druggability of Potential Drug Candidates in Nonalcoholic Fatty Liver Disease Therapy

R Amatya, D Lee, KA Min, MC Shin - Pharmaceutics, 2023 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) has become globally prevalent and is the leading
cause of chronic liver disease. Although NAFLD is reversible without medical intervention in …

[HTML][HTML] Dietary bile acids supplementation improves the growth performance and alleviates fatty liver in broilers fed a high-fat diet via improving the gut microbiota

D Hu, M Hou, P Song, Q Chen, Y Feng, X Wu, Y Ni - Poultry Science, 2024 - Elsevier
This experiment aims to evaluate the effect of bile acids (BAs) in alleviating fatty liver
disease induced by a high-fat diet (HFD) in broilers, and the modulation of the gut microbiota …

The farnesoid X receptor as a master regulator of hepatotoxicity

M Rausch, SL Samodelov, M Visentin… - International Journal of …, 2022 - mdpi.com
The nuclear receptor farnesoid X receptor (FXR, NR1H4) is a bile acid (BA) sensor that links
the enterohepatic circuit that regulates BA metabolism and elimination to systemic lipid …

Osteocalcin and its potential functions for preventing fatty liver hemorrhagic syndrome in poultry

W Tu, Y Zhang, K Jiang, S Jiang - Animals, 2023 - mdpi.com
Simple Summary Fatty liver hemorrhage syndrome is one of the main metabolic diseases in
laying hens, which leads to lipid accumulation, fragile liver, rupture bleeding, and sudden …

Butylparaben induces glycolipid metabolic disorders in mice via disruption of gut microbiota and FXR signaling

H Du, L Cui, X Zhao, Z Yu, T He, B Zhang, X Fan… - Journal of Hazardous …, 2024 - Elsevier
Butylparaben, a common preservative, is widely used in food, pharmaceuticals and personal
care products. Epidemiological studies have revealed the close relationship between …

Patented farnesoid X receptor modulators: a review (2019–present)

A Gioiello, E Rosatelli, B Cerra - Expert Opinion on Therapeutic …, 2024 - Taylor & Francis
ABSTRACT Introduction The Farnesoid X receptor (FXR) is a key transcription factor that is
involved in the bile acid signaling network. The modulation of the FXR activity influences …