FXR agonists for MASH therapy: Lessons and perspectives from obeticholic acid
K Wang, Y Zhang, G Wang, H Hao… - Medicinal Research …, 2024 - Wiley Online Library
Nonalcoholic fatty liver disease, also called metabolic dysfunction‐associated steatotic liver
disease, is the most common liver disease worldwide and has no approved …
disease, is the most common liver disease worldwide and has no approved …
Therapeutic implications of impaired nuclear receptor function and dysregulated metabolism in Wilson's disease
CR Wooton-Kee - Pharmacology & Therapeutics, 2023 - Elsevier
Copper is an essential trace element that is required for the activity of many enzymes and
cellular processes, including energy homeostasis and neurotransmitter biosynthesis; …
cellular processes, including energy homeostasis and neurotransmitter biosynthesis; …
AICAR Ameliorates Non-Alcoholic Fatty Liver Disease via Modulation of the HGF/NF-κB/SNARK Signaling Pathway and Restores Mitochondrial and Endoplasmic …
DH Zineldeen, NM Tahoon, NI Sarhan - International Journal of …, 2023 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is a global health problem characterized by
altered lipid and redox homeostasis, mitochondrial dysfunction, and endoplasmic reticulum …
altered lipid and redox homeostasis, mitochondrial dysfunction, and endoplasmic reticulum …
Integration of transcriptomics and metabonomics revealed the protective effects of hemp seed oil against methionine–choline-deficient diet-induced non-alcoholic …
M Gong, H Lu, L Li, M Feng, Z Zou - Food & Function, 2023 - pubs.rsc.org
Non-alcoholic steatohepatitis (NASH) is a chronic liver disease with few therapeutic options
available currently. Hemp seed oil extracted from the seeds of hemp (Cannabis sativa L.) …
available currently. Hemp seed oil extracted from the seeds of hemp (Cannabis sativa L.) …
Pharmaceutical Strategies to Improve Druggability of Potential Drug Candidates in Nonalcoholic Fatty Liver Disease Therapy
Nonalcoholic fatty liver disease (NAFLD) has become globally prevalent and is the leading
cause of chronic liver disease. Although NAFLD is reversible without medical intervention in …
cause of chronic liver disease. Although NAFLD is reversible without medical intervention in …
[HTML][HTML] Dietary bile acids supplementation improves the growth performance and alleviates fatty liver in broilers fed a high-fat diet via improving the gut microbiota
D Hu, M Hou, P Song, Q Chen, Y Feng, X Wu, Y Ni - Poultry Science, 2024 - Elsevier
This experiment aims to evaluate the effect of bile acids (BAs) in alleviating fatty liver
disease induced by a high-fat diet (HFD) in broilers, and the modulation of the gut microbiota …
disease induced by a high-fat diet (HFD) in broilers, and the modulation of the gut microbiota …
The farnesoid X receptor as a master regulator of hepatotoxicity
M Rausch, SL Samodelov, M Visentin… - International Journal of …, 2022 - mdpi.com
The nuclear receptor farnesoid X receptor (FXR, NR1H4) is a bile acid (BA) sensor that links
the enterohepatic circuit that regulates BA metabolism and elimination to systemic lipid …
the enterohepatic circuit that regulates BA metabolism and elimination to systemic lipid …
Osteocalcin and its potential functions for preventing fatty liver hemorrhagic syndrome in poultry
W Tu, Y Zhang, K Jiang, S Jiang - Animals, 2023 - mdpi.com
Simple Summary Fatty liver hemorrhage syndrome is one of the main metabolic diseases in
laying hens, which leads to lipid accumulation, fragile liver, rupture bleeding, and sudden …
laying hens, which leads to lipid accumulation, fragile liver, rupture bleeding, and sudden …
Butylparaben induces glycolipid metabolic disorders in mice via disruption of gut microbiota and FXR signaling
H Du, L Cui, X Zhao, Z Yu, T He, B Zhang, X Fan… - Journal of Hazardous …, 2024 - Elsevier
Butylparaben, a common preservative, is widely used in food, pharmaceuticals and personal
care products. Epidemiological studies have revealed the close relationship between …
care products. Epidemiological studies have revealed the close relationship between …
Patented farnesoid X receptor modulators: a review (2019–present)
A Gioiello, E Rosatelli, B Cerra - Expert Opinion on Therapeutic …, 2024 - Taylor & Francis
ABSTRACT Introduction The Farnesoid X receptor (FXR) is a key transcription factor that is
involved in the bile acid signaling network. The modulation of the FXR activity influences …
involved in the bile acid signaling network. The modulation of the FXR activity influences …