Redox regulation participates in the control of various aspects of metabolism. Reactive
oxygen and nitrogen species participate in many reactions under physiological conditions …

Heart diseases and related complications constitute a leading cause of death and
socioeconomic threat worldwide. Despite intense efforts and research on the pathogenetic …

Introduction Bitter taste receptors (T2Rs) are G protein-coupled receptors identified on the
tongue but expressed all over the body, including in airway cilia and macrophages, where …

Severe early childhood caries (S-ECC) is a multifactorial disease with strong evidence of
genetic inheritance. Previous studies suggest that variants in taste genes are associated …

Bitter taste receptors (TAS2Rs) have recently arisen as a potential drug target for asthma
due to their localization in airway cells. These receptors are expressed in all cell types of the …

Bitter and sweet taste G protein-coupled receptors (known as T2Rs and T1Rs, respectively)
were originally identified in type II taste cells on the tongue, where they signal perception of …

Global warming has direct and indirect effects, as well as short-and long-term impacts on the
respiratory and skin barriers. Extreme temperature directly affects the airway epithelial …

Bacterial pneumonia greatly contributes to the disease burden and mortality of lower
respiratory tract infections among all age groups and risk profiles. Therefore, laboratory …

Abstract Background The role of Akt in nasal immunity is unstudied. Akt phosphorylates and
activates endothelial nitric oxide synthase (eNOS) expressed in epithelial ciliated cells. Nitric …

Bitter (T2R) and sweet/umami (T1R) taste receptors serve diverse chemosensory roles all
over the body. In airway motile cilia, T2Rs detect bacterial quinolones and lactones to …