Effects of Akt Activator SC79 on Human M0 Macrophage Phagocytosis and Cytokine Production

RJ Lee, ND Adappa, JN Palmer - Cells, 2024 - mdpi.com
Akt is an important kinase in metabolism. Akt also phosphorylates and activates endothelial
and neuronal nitric oxide (NO) synthases (eNOS and nNOS, respectively) expressed in M0 …

How effective is topical miconazole or amorolfine for mild to moderately severe onychomycosis in primary care: the Onycho Trial–a randomised double-blind placebo …

RM Watjer, TN Bonten, K Sayed, KD Quint… - BMJ open, 2024 - bmjopen.bmj.com
Objectives To evaluate the efficacy of topical miconazole or amorolfine compared to placebo
for mild to moderately severe onychomycosis. Design Randomised, double-blind, placebo …

Taste receptor T1R3 in nasal cilia detects Staphylococcus aureus D-amino acids to enhance apical glucose uptake

RM Carey, ND Adappa, JN Palmer, NA Cohen, RJ Lee - BioRxiv, 2022 - biorxiv.org
Bitter (T2R) and sweet/umami (T1R) taste receptors serve diverse chemosensory roles all
over the body. In airway motile cilia, T2Rs detect bacterial quinolones and lactones to …

GPRC5A promotes paclitaxel resistance and glucose content in NSCLC

Y Wang, L Gao, F Wang, C Yu, C Chen… - Anti-Cancer Drugs, 2024 - journals.lww.com
Lung cancer is one of the most common and malignant cancers worldwide. Chemotherapy
has been widely used in the clinical setting, and paclitaxel is the first-line therapy for lung …

[HTML][HTML] Identification of the material basis of the medicinal properties in Curcuma Longa L. to enhance targeted clinical application

S Peng, J Li, M Huo, Y Cao, Z Chen, Y Zhang… - Journal of Traditional …, 2022 - Elsevier
Objective To identify the relationship between the active compounds in turmeric (Curcuma
Longa L., C. Longa) and their medicinal properties, and clarify the chemical material basis of …

Bitter taste receptor-stimulated nitric oxide innate immune responses are reduced by loss of CFTR function in nasal epithelial cells and macrophages

RM Carey, JN Palmer, ND Adappa, RJ Lee - bioRxiv, 2022 - biorxiv.org
Bitter taste receptors (T2Rs) are G protein-coupled receptors identified on the tongue but
expressed all over the body, including in airway cilia and macrophages, where T2Rs serve …

Akt activator SC79 stimulates antibacterial nitric oxide production from human nasal epithelial cells and increases macrophage phagocytosis in vitro

RJ Lee, ND Adappa, JN Palmer - bioRxiv, 2022 - biorxiv.org
Background The role of the Akt serine/threonine kinase family in airway innate immunity is
relatively unstudied compared with other pathways. Akt can phosphorylate and activate the …

An Examination of the Relationship Between the Individual T2R Phenotype and Health Outcome Among COVID-19 Patients in Louisiana: Policy Implications

SH Westbrook - 2023 - search.proquest.com
This study examines the relationship between the individual bitter taste receptors (T2R)
phenotype and health outcomes among COVID-19 patients in Louisiana to inform and guide …

[引用][C] Phenotypic and genotypic associations between food allergy and taste

Z Shao - 2023 - espace.library.uq.edu.au
Food allergies (FA) have been a growing public health concern with increasing prevalence
worldwide. FA may cause mild to critical health symptoms seldomly becoming fatal in the …