Dementia is a chronic or progressive syndrome, characterized by impaired cognitive
capacity beyond what could be considered a consequence of normal aging. It affects the …

AD is a progressive neurodegenerative disorder and a leading cause of dementia in an
aging population worldwide. The enormous challenge which AD possesses to global …

Mind how you go: The current strategies for the development of therapies for Alzheimer's
disease are very diverse. Particular attention is given to the search for inhibitors (see picture …

Alzheimer's disease (AD) is characterized by a progressive phenotypic downregulation of
markers within cholinergic basal forebrain (CBF) neurons, frank CBF cell loss and reduced …

Aggregation of amyloid-β (Aβ) as toxic oligomers and amyloid plaques within the brain
appears to be the pathogenic event that initiates Alzheimer's disease (AD) lesions. One …

Schizophrenia remains a challenging disease to treat effectively with current antipsychotic
medications due to their limited efficacy across the entire spectrum of core symptoms as well …

This comprehensive, pedagogically-oriented review is aimed at a heterogeneous audience
representative of the allied disciplines involved in research and patient care. After a …

Tobacco smoking is an extremely addictive and harmful form of nicotine (NIC) consumption,
but unfortunately also the most prevalent. Although disproportionately high frequencies of …

The aging population increases steadily because of a healthy lifestyle and medical
advancements in healthcare. However, Alzheimer's disease (AD) is becoming more …

The muscarinic cholinergic system constitutes an important part of the neuronal circuitry that
modulates normal cognition. Muscarinic receptor antagonists are well known to produce or …