Traumatic brain injury (TBI) is a major medical and socio-economic problem, and is the
leading cause of death in children and young adults. The critical care management of …

Background Microdialysis is used in many European neurointensive care units to monitor
brain chemistry in patients suffering subarachnoid hemorrhage (SAH) or traumatic brain …

Microdialysis enables the chemistry of the extracellular interstitial space to be monitored.
Use of this technique in patients with acute brain injury has increased our understanding of …

Disturbed glucose brain metabolism after brain trauma is reflected by changes in
extracellular glucose levels. The authors hypothesized that posttraumatic reductions in …

The enduring cognitive deficits and histopathology associated with traumatic brain injury
(TBI) may arise from damage to mitochondrial populations, which initiates the metabolic …

Object Preclinical and clinical investigations indicate that the positive effect of hyperbaric
oxygen (HBO 2) for severe traumatic brain injury (TBI) occurs after rather than during …

Object. The effect of normobaric hyperoxia (fraction of inspired O 2 [FIO 2] concentration
100%) in the treatment of patients with traumatic brain injury (TBI) remains controversial. The …

Rapid detection of ischemic conditions at the bedside can improve treatment of acute brain
injury. In this observational study of 11 critically ill brain-injured adults, we employed a …

Background In patients with severe traumatic brain lesions, the lower limit for cerebral
perfusion pressure (CPP) is controversial. The aim of this prospective study was to assess …

Cerebral microdialysis is a well-established laboratory tool that is increasingly used as a
bedside monitor to provide on-line analysis of brain tissue biochemistry during …