Frontiers in the treatment of glioblastoma: Past, present and emerging

TI Janjua, P Rewatkar, A Ahmed-Cox, I Saeed… - Advanced drug delivery …, 2021 - Elsevier
Glioblastoma (GBM) is one of the most aggressive cancers of the brain. Despite extensive
research over the last several decades, the survival rates for GBM have not improved and …

[HTML][HTML] Glioblastoma: overview of disease and treatment

ME Davis - Clinical journal of oncology nursing, 2016 - ncbi.nlm.nih.gov
Background Glioblastoma (GBM) is the most common and aggressive malignant brain tumor
in adults. Current treatment options at diagnosis are multimodal and include surgical …

Engineered biomimetic nanoparticles achieve targeted delivery and efficient metabolism-based synergistic therapy against glioblastoma

G Lu, X Wang, F Li, S Wang, J Zhao, J Wang… - Nature …, 2022 - nature.com
Glioblastoma multiforme (GBM) is an aggressive brain cancer with a poor prognosis and few
treatment options. Here, building on the observation of elevated lactate (LA) in resected …

Exosomal noncoding RNAs in Glioma: biological functions and potential clinical applications

J Cheng, J Meng, L Zhu, Y Peng - Molecular cancer, 2020 - Springer
Gliomas are complex and heterogeneous brain tumors with poor prognosis. Glioma cells
can communicate with their surroundings to create a tumor-permissive microenvironment …

Mechanisms of resistance and current treatment options for glioblastoma multiforme (GBM)

SSK Yalamarty, N Filipczak, X Li, MA Subhan… - Cancers, 2023 - mdpi.com
Simple Summary Glioblastoma multiforme is one of the hardest-to-treat brain tumors, often
resistant to conventional treatments such as chemotherapy and radiation therapy. Despite …

[HTML][HTML] Magnetic iron oxide nanoparticles for imaging, targeting and treatment of primary and metastatic tumors of the brain

LL Israel, A Galstyan, E Holler, JY Ljubimova - Journal of Controlled …, 2020 - Elsevier
Magnetic nanoparticles in general, and iron oxide nanoparticles in particular, have been
studied extensively during the past 20 years for numerous biomedical applications. The …

Current and future strategies for treatment of glioma

NAO Bush, SM Chang, MS Berger - Neurosurgical review, 2017 - Springer
Gliomas are one of the most common types of primary brain tumors and have remained
particularly challenging to treat. This review illustrates a multidisciplinary approach to the …

Systemic brain tumor delivery of synthetic protein nanoparticles for glioblastoma therapy

JV Gregory, P Kadiyala, R Doherty, M Cadena… - Nature …, 2020 - nature.com
Glioblastoma (GBM), the most aggressive form of brain cancer, has witnessed very little
clinical progress over the last decades, in part, due to the absence of effective drug delivery …

Diagnostic and therapeutic biomarkers in glioblastoma: current status and future perspectives

W Szopa, TA Burley, G Kramer-Marek… - BioMed research …, 2017 - Wiley Online Library
Glioblastoma (GBM) is a primary neuroepithelial tumor of the central nervous system,
characterized by an extremely aggressive clinical phenotype. Patients with GBM have a …

ROS‐responsive polymeric siRNA nanomedicine stabilized by triple interactions for the robust glioblastoma combinational RNAi therapy

M Zheng, Y Liu, Y Wang, D Zhang, Y Zou… - Advanced …, 2019 - Wiley Online Library
Small interfering RNA (siRNA) holds inherent advantages and great potential for treating
refractory diseases. However, lack of suitable siRNA delivery systems that demonstrate …