Purpose The anticancer agent, cyclophosphamide, is metabolized by cytochrome P450
(CYP), glutathione S-transferase (GST) and aldehyde dehydrogenase (ALDH) enzymes …

Imatinib has so far been the first-choice treatment in chronic myeloid leukemia with excellent
results. However, only a proportion of patients achieve major molecular response–hence the …

Contamination is a potential problem in the study of ancient proteins, either from prior
handling of the sample, laboratory consumables, or cross-sample carryover from mass …

Purpose: Despite the extensive clinical experience with docetaxel, unpredictable
interindividual variability in efficacy and toxicity remain important limitations associated with …

Fetal liver CYP3A7 plays an important role in placental estriol synthesis during pregnancy,
yet little is known concerning the extent or consequences of variability in expression. The …

Objective Patients expressing the tacrolimus-metabolizing enzyme, cytochrome P450 (CYP)
3A5, require more tacrolimus to reach target concentrations. We studied the influence of the …

CYP3A isozymes participate in the metabolism of 45–60% of currently used drugs and of a
variety of other compounds such as steroid hormones, toxins, and carcinogens. The CYP3A …

Effects of the CYP3A4 intron 6 C> T (CYP3A4* 22) polymorphism, which has recently been
reported to have a critical role in vivo, were investigated by measuring CYP3A4 protein …

The aim of this review is to discuss our current understanding of the developmental changes
of the drug-metabolizing enzyme cytochrome P450 (CYP) 3A and its impact on drug therapy …

Objective Our objective was to investigate the population pharmacokinetics of tacrolimus in
pediatric living‐donor liver transplant recipients and examine the effects of the multidrug …