In a large proportion of individuals nervous system damage may lead to a debilitating
chronic neuropathic pain. Such pain may now be considered a neuro-immune disorder …

This review is focused on purinergic neurotransmission, ie, ATP released from nerves as a
transmitter or cotransmitter to act as an extracellular signaling molecule on both pre-and …

Tissue damage, inflammation or injury of the nervous system may result in chronic
neuropathic pain characterised by increased sensitivity to painful stimuli (hyperalgesia), the …

Damage to the peripheral nervous system often leads to chronic neuropathic pain
characterized by spontaneous pain and an exaggerated response to painful and/or …

All cells release nucleotides and are in one way or another involved in local autocrine and
paracrine regulation of organ function via stimulation of purinergic receptors. Significant …

Müller cells and macrophages/microglia are likely important for the development of diabetic
retinopathy; however, the interplay between these cells in this disease is not well …

The functional and structural integrity of the nervous system depends on the coordinated
action of neurons and glial cells. Phenomena like synaptic activity, conduction of action …

In the first 20 years that followed the purinergic signalling hypothesis in 1972, most scientists
were sceptical about its validity, largely because ATP was so well established as an …

Exosomes, nano‐sized extracellular vesicles, are produced via the endosomal pathway and
released in the extracellular space upon fusion of multivesicular bodies with the plasma …

Gap junction communication is crucial for myelination and axonal survival in both the
peripheral nervous system (PNS) and central nervous system (CNS). This review examines …