Craniosynostosis, the premature fusion of one or more cranial sutures of the skull, provides
a paradigm for investigating the interplay of genetic and environmental factors leading to …

Mutations in fibroblast growth factor receptors (Fgfrs) are the etiology of many
craniosynostosis and chondrodysplasia syndromes in humans. The phenotypes associated …

The discovery in 1994 that highly specific mutations of fibroblast growth factor (FGF) receptor
3 caused the most common form of human short-limbed dwarfism, achondroplasia, heralded …

Fibroblast growth factor (FGF)-23 has emerged as an endocrine regulator of phosphate and
of vitamin D metabolism. It is produced in bone and, unlike other FGFs, circulates in the …

The prototypical fibroblast growth factor receptor (FGFR) extracellular domain consists of
three Ig domains (D1–D3) of which the two membrane-proximal D2 and D3 domains and the …

FGFR3 is a receptor tyrosine kinase (RTK) of the FGF receptor family, known to have a
negative regulatory effect on long bone growth. Fgfr3 knockout mice display longer bones …

Fibroblast growth factors (FGFs) and their receptors (FGFRs) are transmembrane growth
factor receptors with wide tissue distribution. FGF/FGFR signaling is involved in neoplastic …

The current working model for fibroblast growth factor receptor (FGFR) dimerization and
activation requires the assembly of a ternary complex of fibroblast growth factor (FGF) …

Two of the four human FGF8 splice isoforms, FGF8a and FGF8b, are expressed in the mid-
hindbrain region during development. Although the only difference between these isoforms …

Heparan sulfate (HS) is an essential and dynamic regulator of fibroblast growth factor (FGF)
signaling. Two fundamentally different crystallographic models have been proposed to …