Aggregation-induced emission (AIE), life and health

H Wang, Q Li, P Alam, H Bai, V Bhalla, MR Bryce… - ACS …, 2023 - ACS Publications
Light has profoundly impacted modern medicine and healthcare, with numerous
luminescent agents and imaging techniques currently being used to assess health and treat …

Biomarker-activatable probes based on smart AIEgens for fluorescence and optoacoustic imaging

J Ouyang, L Sun, F Zeng, S Wu - Coordination Chemistry Reviews, 2022 - Elsevier
Fluorophores with aggregation-induced emission (AIE) are characterized by many
advantageous features for biomedical applications, including excellent photostability and …

A photo-triggered self-accelerated nanoplatform for multifunctional image-guided combination cancer immunotherapy

X Kang, Y Zhang, J Song, L Wang, W Li, J Qi… - Nature …, 2023 - nature.com
Precise and efficient image-guided immunotherapy holds great promise for cancer
treatment. Here, we report a self-accelerated nanoplatform combining an aggregation …

Engineered NIR-II fluorophores with ultralong-distance molecular packing for high-contrast deep lesion identification

Z Feng, Y Li, S Chen, J Li, T Wu, Y Ying… - Nature …, 2023 - nature.com
The limited signal of long-wavelength near-infrared-II (NIR-II, 900–1880 nm) fluorophores
and the strong background caused by the diffused photons make high-contrast fluorescence …

AIE-active luminogens as highly efficient free-radical ROS photogenerator for image-guided photodynamic therapy

Z Liu, Q Wang, W Qiu, Y Lyu, Z Zhu, X Zhao… - Chemical Science, 2022 - pubs.rsc.org
Image-guided photodynamic therapy (PDT) can realize highly precise and effective therapy
via the integration of imaging and therapy, and has created high requirements for …

Cucurbit [8] uril-based water-dispersible assemblies with enhanced optoacoustic performance for multispectral optoacoustic imaging

Y Wu, L Sun, X Chen, J Liu, J Ouyang, X Zhang… - Nature …, 2023 - nature.com
Organic small-molecule contrast agents have attracted considerable attention in the field of
multispectral optoacoustic imaging, but their weak optoacoustic performance resulted from …

An AIEgen-based oral-administration nanosystem for detection and therapy of ulcerative colitis via 3D-MSOT/NIR-II fluorescent imaging and inhibiting NLRP3 …

L Sun, J Ouyang, F Zeng, S Wu - Biomaterials, 2022 - Elsevier
Ulcerative colitis is the most prevalent forms of inflammatory bowel diseases and a refractory
autoimmune disease and affects millions of people worldwide. Herein, we develop an oral …

Construction of Long‐Wavelength Emissive Organic Nanosonosensitizer Targeting Mitochondria for Precise and Efficient In Vivo Sonotherapy

X Zhang, C Li, Y Zhang, X Guan, L Mei… - Advanced Functional …, 2022 - Wiley Online Library
As a modern biomedical therapeutic modality, sonodynamic therapy (SDT) presents unique
advantages, including superior tissue penetration capability, temporal–spatial controllability …

Renal-clearable probe with water solubility and photostability for biomarker-activatable detection of acute kidney injuries via NIR-II fluorescence and optoacoustic …

C Zeng, Y Tan, L Sun, Y Long, F Zeng… - Acs Applied Materials & …, 2023 - ACS Publications
Acute kidney injuries (AKI) have serious short-term or long-term complications with high
morbidity and mortality rate, thus posing great health threats. Developing high-performance …

Viscosity-responsive NIR-II fluorescent probe with aggregation-induced emission features for early diagnosis of liver injury

J Ge, W Cai, N Niu, Y Wen, Q Wu, L Wang, D Wang… - Biomaterials, 2023 - Elsevier
As the primary organ for drug metabolism and detoxification, the liver is susceptible to
damage and seriously impaired function. In situ diagnosing and real-time monitoring of liver …