New-age vaccine adjuvants, their development, and future perspective

SK Verma, P Mahajan, NK Singh, A Gupta… - Frontiers in …, 2023 - frontiersin.org
In the present scenario, immunization is of utmost importance as it keeps us safe and
protects us from infectious agents. Despite the great success in the field of vaccinology …

[HTML][HTML] Polysaccharide-based nanomedicines for cancer immunotherapy: A review

Y Zeng, Y Xiang, R Sheng, H Tomás, J Rodrigues… - Bioactive Materials, 2021 - Elsevier
Cancer immunotherapy is an effective antitumor approach through activating immune
systems to eradicate tumors by immunotherapeutics. However, direct administration of …

Delivery of mRNA vaccine with a lipid-like material potentiates antitumor efficacy through Toll-like receptor 4 signaling

H Zhang, X You, X Wang, L Cui… - Proceedings of the …, 2021 - National Acad Sciences
Intracellular delivery of messenger RNA (mRNA)-based cancer vaccine has shown great
potential to elicit antitumor immunity. To achieve robust antitumor efficacy, mRNA encoding …

Adjuvant-pulsed mRNA vaccine nanoparticle for immunoprophylactic and therapeutic tumor suppression in mice

MA Islam, J Rice, E Reesor, H Zope, W Tao, M Lim… - Biomaterials, 2021 - Elsevier
Synthetic mRNA represents an exciting cancer vaccine technology for the implementation of
effective cancer immunotherapy. However, inefficient in vivo mRNA delivery along with a …

Mechanisms of macrophage plasticity in the tumor environment: manipulating activation state to improve outcomes

TD Ricketts, N Prieto-Dominguez, PS Gowda… - Frontiers in …, 2021 - frontiersin.org
Macrophages are a specialized class of innate immune cells with multifaceted roles in
modulation of the inflammatory response, homeostasis, and wound healing. While …

Development and validation of a robust ferroptosis-related prognostic signature in lung adenocarcinoma

A Zhang, J Yang, C Ma, F Li, H Luo - Frontiers in Cell and …, 2021 - frontiersin.org
Background Lung adenocarcinoma (LUAD) is the most common subtype of non-small cell
lung cancer. Ferroptosis is a newly recognized process of cell death, which is different from …

Potential effects of gut microbiota on host cancers: focus on immunity, DNA damage, cellular pathways, and anticancer therapy

J Sun, F Chen, G Wu - The ISME Journal, 2023 - academic.oup.com
The symbiotic bacteria that live in the human gut and the metabolites they produce have
long influenced local and systemic physiological and pathological processes of the host …

An overview of nanocarrier-based adjuvants for vaccine delivery

KC Petkar, SM Patil, SS Chavhan, K Kaneko… - Pharmaceutics, 2021 - mdpi.com
The development of vaccines is one of the most significant medical accomplishments which
has helped to eradicate a large number of diseases. It has undergone an evolutionary …

Fluoroalkane modified cationic polymers for personalized mRNA cancer vaccines

J Li, Y Wu, J Xiang, H Wang, Q Zhuang, T Wei… - Chemical Engineering …, 2023 - Elsevier
Messenger RNA (mRNA) vaccines, while demonstrating great successes in the fight against
COVID-19, have been extensively studied in other areas such as personalized cancer …

Therapeutic targeting of TLR4 for inflammation, infection, and cancer: a perspective for disaccharide lipid A mimetics

H Heine, A Zamyatina - Pharmaceuticals, 2022 - mdpi.com
The Toll-like receptor 4 (TLR4) signaling pathway plays a central role in the prompt defense
against infectious challenge and provides immediate response to Gram-negative bacterial …